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Cellosaurus S1-B1-20 (CVCL_0H85)

[Text version]
Cell line name S1-B1-20
Synonyms S1B1-20; S1B20
Accession CVCL_0H85
Resource Identification Initiative To cite this cell line use: S1-B1-20 (RRID:CVCL_0H85)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:88337; Bisantrene.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0H88 (S1)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=7865904
Zhang X.P., Ritke M.K., Yalowich J.C., Slovak M.L., Ho J.P., Collins K.I., Annable T., Arceci R.J., Durr F.E., Greenberger L.M.
P-glycoprotein mediates profound resistance to bisantrene.
Oncol. Res. 6:291-301(1994)

PubMed=9865745
Rabindran S.K., He H.-Y., Singh M., Brown E., Collins K.I., Annable T., Greenberger L.M.
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.
Cancer Res. 58:5850-5858(1998)

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0H85
Chemistry resources ChEMBL-Cells; CHEMBL3307291
ChEMBL-Targets; CHEMBL614053
PubChem_Cell_line; CVCL_0H85
Encyclopedic resources Wikidata; Q54951788
Entry history
Entry creation10-Apr-2015
Last entry update05-Oct-2023
Version number15