ID   S1-B1-20
AC   CVCL_0H85
SY   S1B1-20; S1B20
DR   cancercelllines; CVCL_0H85
DR   ChEMBL-Cells; CHEMBL3307291
DR   ChEMBL-Targets; CHEMBL614053
DR   PubChem_Cell_line; CVCL_0H85
DR   Wikidata; Q54951788
RX   PubMed=7865904;
RX   PubMed=9865745;
RX   PubMed=11406094;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:88337; Bisantrene.
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0H88 ! S1
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 05-10-23; Version: 15
//
RX   PubMed=7865904;
RA   Zhang X.P., Ritke M.K., Yalowich J.C., Slovak M.L., Ho J.P.,
RA   Collins K.I., Annable T., Arceci R.J., Durr F.E., Greenberger L.M.;
RT   "P-glycoprotein mediates profound resistance to bisantrene.";
RL   Oncol. Res. 6:291-301(1994).
//
RX   PubMed=9865745;
RA   Rabindran S.K., He H.-Y., Singh M., Brown E., Collins K.I., Annable T.,
RA   Greenberger L.M.;
RT   "Reversal of a novel multidrug resistance mechanism in human colon
RT   carcinoma cells by fumitremorgin C.";
RL   Cancer Res. 58:5850-5858(1998).
//
RX   PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X;
RA   Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T.,
RA   Litman T., Bates S.E.;
RT   "A functional assay for detection of the mitoxantrone resistance
RT   protein, MXR (ABCG2).";
RL   Biochim. Biophys. Acta 1512:171-182(2001).
//