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Cellosaurus WRL 68 (CVCL_0581)

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Cell line name WRL 68
Synonyms WRL-68; WRL68
Accession CVCL_0581
Secondary accession CVCL_D685
Resource Identification Initiative To cite this cell line use: WRL 68 (RRID:CVCL_0581)
Comments Group: Patented cell line.
Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=20143388). Originally thought to be a hepatic fetal epithelial cell line.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00351.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-48.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Misspelling: CL-48; Note=Based on the ATCC catalog number.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_4W86 (WRLS1)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): ATCC=CL-48; ECACC=89121403

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135815,18
D5S81811,12
D7S8208,12
D8S117912,13
D13S31712,13.3 (ATCC=CL-48)
12,14 (ECACC=89121403)
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28
FGA18,21
Penta D8,15
Penta E7,17
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

Patent=CA999546A
Kostadin Apostolov;
Human liver cell line.
Patent number CA999546A, 09-Nov-1976

Patent=US3935066
Kostadin Apostolov;
Cell lines.
Patent number US3935066, 27-Jan-1976

PubMed=8389256; DOI=10.1093/carcin/14.5.987
Ih-Chang Hsu, Takayoshi Tokiwa, William P. Bennett, Robert A. Metcalf, Judith A. Welsh, Tsung-Tang Sun, Curtis Craig Harris;
p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines.
Carcinogenesis 14:987-992(1993)

PubMed=7522099; DOI=10.1007/BF02634356
Maria Concepcion Gutierrez-Ruiz, Leticia Bucio Ortiz, Veronica Souza, J.J. Gomez, Carolina Campos, Alfonso Carabez-Trejo;
Expression of some hepatocyte-like functional properties of WRL-68 cells in culture.
In Vitro Cell. Dev. Biol. Anim. 30:366-371(1994)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) ATCC; CL-48
BCRC; 60338 - Discontinued
ECACC; 89121403
IZSLER; BS CL 173
Cell line databases/resources CLO; CLO_0009633
MCCL; MCC:0000487
CLDB; cl4730
Anatomy/cell type resources BTO; BTO_0002584
Biological sample resources BioSample; SAMN03151767
Chemistry resources ChEMBL-Cells; CHEMBL3307993
ChEMBL-Targets; CHEMBL612587
PubChem_Cell_line; CVCL_0581
Encyclopedic resources Wikidata; Q54994415
Experimental variables resources EFO; EFO_0022716
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number31