ID   WRL 68
AC   CVCL_0581
AS   CVCL_D685
SY   WRL-68; WRL68
DR   BTO; BTO_0002584
DR   CLO; CLO_0009633
DR   EFO; EFO_0022716
DR   MCCL; MCC:0000487
DR   CLDB; cl4730
DR   ATCC; CL-48
DR   BCRC; 60338
DR   BioSample; SAMN03151767
DR   ChEMBL-Cells; CHEMBL3307993
DR   ChEMBL-Targets; CHEMBL612587
DR   ECACC; 89121403
DR   IZSLER; BS CL 173
DR   PubChem_Cell_line; CVCL_0581
DR   Wikidata; Q54994415
RX   Patent=CA999546A;
RX   Patent=US3935066;
RX   PubMed=7522099;
RX   PubMed=8389256;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Group: Patented cell line.
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=20143388). Originally thought to be a hepatic fetal epithelial cell line.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00351.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-48.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Misspelling: CL-48; Note=Based on the ATCC catalog number.
CC   Discontinued: BCRC; 60338; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): ATCC=CL-48; ECACC=89121403
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 12,13.3 (ATCC=CL-48)
ST   D13S317: 12,14 (ECACC=89121403)
ST   D16S539: 9,10
ST   D18S51: 16
ST   D19S433: 13,14
ST   D21S11: 27,28
ST   D2S1338: 17
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 12,13
ST   FGA: 18,21
ST   Penta D: 8,15
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
CH   CVCL_4W86 ! WRLS1
//
RX   Patent=CA999546A;
RA   Apostolov, Kostadin
RT   "Human liver cell line.";
RL   Patent number CA999546A, 09-Nov-1976.
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   Patent=US3935066;
RA   Apostolov, Kostadin
RT   "Cell lines.";
RL   Patent number US3935066, 27-Jan-1976.
//
RX   PubMed=8389256; DOI=10.1093/carcin/14.5.987;
RA   Hsu, Ih-Chang
RA   Tokiwa, Takayoshi
RA   Bennett, William P.
RA   Metcalf, Robert A.
RA   Welsh, Judith A.
RA   Sun, Tsung-Tang
RA   Harris, Curtis Craig
RT   "p53 gene mutation and integrated hepatitis B viral DNA sequences in
RT   human liver cancer cell lines.";
RL   Carcinogenesis 14:987-992(1993).
//
RX   PubMed=7522099; DOI=10.1007/BF02634356;
RA   Gutierrez-Ruiz, Maria Concepcion
RA   Bucio Ortiz, Leticia
RA   Souza, Veronica
RA   Gomez, J.J.
RA   Campos, Carolina
RA   Carabez-Trejo, Alfonso
RT   "Expression of some hepatocyte-like functional properties of WRL-68
RT   cells in culture.";
RL   In Vitro Cell. Dev. Biol. Anim. 30:366-371(1994).
//