Home  |  Contact

Cellosaurus SK-N-BE(2)-C (CVCL_0529)

[Text version]

Cell line name SK-N-BE(2)-C
Synonyms SK-N-BE(2)C; SK-N-BE-2c; SK-N-BE2(c); SK-N-BE(2C); SK-N-BE(2c); SK-N-BE2C; SK_N_BE2C; SKNBE2C; SKNBE(2c); BE(2)-C; BE(2)C; Be(2)C; BE2-C; BE2_C; Be2-C; BE2C; Be2C
Accession CVCL_0529
Resource Identification Initiative To cite this cell line use: SK-N-BE(2)-C (RRID:CVCL_0529)
Comments Part of: ENCODE project common cell types; tier 3.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-532.
Population: Caucasian.
Characteristics: Intermediate type (I-type) (PubMed=15720811).
Characteristics: MYCN-amplified NBL cell line.
Doubling time: 18 hours (ATCC).
Omics: Array-based CGH.
Omics: ATAC-seq.
Omics: CTCF ChIP-seq epigenome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Single cell RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Heterozygous (PubMed=11196202).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Heterozygous (PubMed=11196202).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0528 (SK-N-BE(2))
CVCL_V006 (BE(2)-C/ADR(5) )CVCL_V007 (BE(2)-C/ACT(0.2) )CVCL_V008 (BE(2)-C/CHC(1) )
CVCL_V009 (BE(2)-C/CHCb )CVCL_V010 (BE(2)-C/CHCg )CVCL_B7TE (SK/IFN-gamma )
CVCL_B7TF (SK/neo )
Sex of cell Male
Age at sampling 2Y2M
Category Cancer cell line
STR profile Source(s): ATCC; ECACC


Run an STR similarity search on this cell line
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/BE2-C_Myers_protocol.pdf

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

PubMed=1985865; DOI=10.1002/ijc.2910470119
Lashford L.S., Hancock J.P., Kemshead J.T.
Meta-iodobenzylguanidine (mIBG) uptake and storage in the human neuroblastoma cell line SK-N-BE(2C).
Int. J. Cancer 47:105-109(1991)

PubMed=8665486; DOI=10.1016/0304-3835(96)04250-4
Diccianni M.B., Chau L.S., Batova A., Vu T.Q., Yu A.L.-T.
The p16 and p18 tumor suppressor genes in neuroblastoma: implications for drug resistance.
Cancer Lett. 104:183-192(1996)

PubMed=10630978; DOI=10.1667/0033-7587(2000)153[0062:FORIMI]2.0.CO;2
Akudugu J.M., Slabbert J.P., Serafin A., Bohm L.
Frequency of radiation-induced micronuclei in neuronal cells does not correlate with clonogenic survival.
Radiat. Res. 153:62-67(2000)

Tweddle D.A., Malcolm A.J., Bown N., Pearson A.D., Lunec J.
Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line.
Cancer Res. 61:8-13(2001)

PubMed=15150552; DOI=10.1038/sj.bjc.6601842
Airoldi I., Meazza R., Croce M., Di Carlo E., Piazza T., Cocco C., D'Antuono T., Pistoia V., Ferrini S., Corrias M.V.
Low-dose interferon-gamma-producing human neuroblastoma cells show reduced proliferation and delayed tumorigenicity.
Br. J. Cancer 90:2210-2218(2004)

PubMed=15390183; DOI=10.1002/gcc.20096
Gebauer S., Yu A.L.-T., Omura-Minamisawa M., Batova A., Diccianni M.B.
Expression profiles and clinical relationships of ID2, CDKN1B, and CDKN2A in primary neuroblastoma.
Genes Chromosomes Cancer 41:297-308(2004)

PubMed=15720811; DOI=10.1593/neo.04310
Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F., Biedler J.L., Cheung N.-K.V., Ross R.A.
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Neoplasia 6:838-845(2004)

PubMed=15892104; DOI=10.1002/gcc.20198
Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=19147553; DOI=10.1158/0008-5472.CAN-08-1856
Michaelis M., Rothweiler F., Klassert D., von Deimling A., Weber K., Fehse B., Kammerer B., Doerr H.-W., Cinatl J. Jr.
Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3.
Cancer Res. 69:416-421(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23202128; DOI=10.1038/ng.2493
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X.-Y., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=24466371; DOI=10.1593/tlo.13544
Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=26342562; DOI=10.1016/j.scr.2015.08.008
Ross R.A., Walton J.D., Han D., Guo H.-F., Cheung N.-K.V.
A distinct gene expression signature characterizes human neuroblastoma cancer stem cells.
Stem Cell Res. 15:419-426(2015)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

PubMed=33525507; DOI=10.3390/biom11020177
Mercatelli D., Balboni N., Palma A., Aleo E., Sanna P.P., Perini G., Giorgi F.M.
Single-cell gene network analysis and transcriptional landscape of MYCN-amplified neuroblastoma cell lines.
Biomolecules 11:177.1-177.18(2021)

Cell line collections ATCC; CRL-2268
ECACC; 95011817
ICLC; HTL96018
NCBI_Iran; C577
Cell line databases/resources CLO; CLO_0001915
CLO; CLO_0009053
MCCL; MCC:0000428
CLDB; cl413
CLDB; cl4334
Cell_Model_Passport; SIDM01232
Anatomy/cell type resources BTO; BTO:0004782
Biological sample resources BioSample; SAMN03471855
Encyclopedic resources Wikidata; Q54954443
Experimental variables resources EFO; EFO_0005725
Gene expression databases ArrayExpress; E-MTAB-38
GEO; GSM651567
GEO; GSM651568
GEO; GSM945241
GEO; GSM945283
GEO; GSM923434
GEO; GSM1022648
GEO; GSM1022650
GEO; GSM1022653
GEO; GSM2371256
GEO; GSM2394383
GEO; GSM3145690
GEO; GSM4104593
GEO; GSM4104594
GEO; GSM4105343
GEO; GSM4105344
GEO; GSM4105345
GEO; GSM4105346
GEO; GSM4105347
Polymorphism and mutation databases Cosmic; 688061
Cosmic; 922659
Cosmic; 1162003
Cosmic; 1167421
Cosmic; 1526648
IARC_TP53; 15544
Progenetix; CVCL_0529
Proteomic databases PRIDE; PXD003596
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number33