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Cellosaurus SGC-7901 (CVCL_0520)

[Text version]
Cell line name SGC-7901
Synonyms SGC 7901; SGC7901
Accession CVCL_0520
Resource Identification Initiative To cite this cell line use: SGC-7901 (RRID:CVCL_0520)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=26116706; PubMed=28851942). Originally thought to originate from the lymph node of a 56 year old female patient with a gastric carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00577.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Proteome analysis by 2D-DE/MS.
Omics: Transcriptome analysis by microarray.
Miscellaneous: Formerly the CCRID database had 2 entries describing this cell line (3111C0001CCC000236, 3131C0001000700046). They were one of the sources for the STR profile of this entry.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
CVCL_RK37 (SGC-7901/B1)CVCL_RK36 (SGC-7901/B2)CVCL_VU57 (SGC7901/ADR)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=26116706; PubMed=28851942; PubMed=29717028

CSF1PO9,10 (PubMed=26116706; PubMed=29717028)
10 (CCRID; PubMed=28851942)
D3S135815,18 (CCRID; PubMed=26116706; PubMed=29717028)
16,18 (PubMed=28851942)
D7S8208,12 (PubMed=26116706; PubMed=29717028)
12 (CCRID; PubMed=28851942)
D8S117912 (CCRID; PubMed=28851942)
12,13 (PubMed=26116706; PubMed=29717028)
D13S31712,13.3 (PubMed=26116706; PubMed=29717028)
13.3 (CCRID; PubMed=28851942)
D19S43313 (CCRID; PubMed=28851942)
13,14 (PubMed=26116706; PubMed=29717028)
FGA18,21 (CCRID; PubMed=28851942)
21 (PubMed=26116706; PubMed=29717028)
Penta D8,15
Penta E7,17
TPOX8,12 (PubMed=26116706; PubMed=29717028)
12 (CCRID; PubMed=28851942)

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

Yang J.-L., Shen Z.-M., Han J.-X.
A study on the biological characteristics of an established human gastric adenocarcinoma cell line (SGC-7901).
Ke Xue Tong Bao 27:1355-1358(1982)

Lin C.-H., Fu Z.-M., Liu Y.-L., Yang J.-L., Xu J.-F., Chen Q.-S., Chen H.-M.
Investigation of SGC-7901 cell line established from human gastric carcinoma cells.
Chin. Med. J. 97:831-834(1984)

Wang L.-B., Qian B.-W., Xia Y.-X.
Establishment of human gastric cancer cell line (SGC-7901) intraperitoneally transplantable in nude mice.
(In) Recent advances in management of digestive cancers; Toshio T. (eds.); pp.416-418; Springer; Tokyo (1993)

Sekiguchi M., Suzuki T.
Gastric tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York (1994)

PubMed=16038636; DOI=10.1111/j.1745-7254.2005.00149.x
Tang X.-Q., Bi H., Feng J.-Q., Cao J.-G.
Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR.
Acta Pharmacol. Sin. 26:1009-1016(2005)

PubMed=16525997; DOI=10.1002/pmic.200402031
Yang Y.-X., Xiao Z.-Q., Chen Z.-C., Zhang G.-Y., Yi H., Zhang P.-F., Li J.-L., Zhu G.
Proteome analysis of multidrug resistance in vincristine-resistant human gastric cancer cell line SGC7901/VCR.
Proteomics 6:2009-2021(2006)

Chen G., Wang Q.-R., Qiu H., Ke S.-D., Xiang Y., Hu S.-M.
Relationship of cellular drug resistance to proportion of side population cells and expression of Mdr1 and ERCC1 in human gastric cell line SGC7901/OXA.
Shi Jie Hua Ren Xiao Hua Za Zhi 19:1219-1224(2011)

PubMed=22576950; DOI=10.1007/s13277-012-0406-3
Xu Y.-Y., Mao X.-Y., Song Y.-X., Zhao F., Wang Z.-N., Zhang W.-X., Xu H.-M., Jin F.
Midkine confers adriamycin resistance in human gastric cancer cells.
Tumor Biol. 33:1543-1548(2012)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

PubMed=27917905; DOI=10.1038/srep38376
Chen Z.-Z., Li W.-M., Zhang Y., Yu M., Shan L.-F., Yuan D.-Z., Liu F.-R., Fang J.
Establishment of a gastric cancer subline with high metastatic potential using a novel microfluidic system.
Sci. Rep. 6:38376-38376(2016)

PubMed=28498440; DOI=10.3892/ijo.2017.3983
Zhuang K., Zhang L.-X., Zhang X., Tang H.-L., Zhang J., Yan Y., Han K., Guo H.-Q.
Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901.
Int. J. Oncol. 50:2091-2100(2017)

PubMed=28851942; DOI=10.1038/s41598-017-09660-w
Bian X.-C., Yang Z.-L., Feng H.-L., Sun H., Liu Y.-Q.
A combination of species identification and STR profiling identifies cross-contaminated cells from 482 human tumor cell lines.
Sci. Rep. 7:9774-9774(2017)

PubMed=29717028; DOI=10.1042/BSR20180277
Zhang Y.-Q., Yu S.-T., Zhang Z.-Z., Zhao G., Xu J.
Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression.
Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018)

Cell line collections (Providers) CCTCC; GDC0150
Cell line databases/resources MCCL; MCC:0000418
TOKU-E; 3764
Anatomy/cell type resources BTO; BTO:0002392
Chemistry resources ChEMBL-Cells; CHEMBL3307739
ChEMBL-Targets; CHEMBL614909
PubChem_Cell_line; CVCL_0520
Encyclopedic resources Wikidata; Q54953170
Experimental variables resources EFO; EFO_0006293
Gene expression databases GEO; GSM844685
GEO; GSM1374869
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25