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Cellosaurus SGC-7901 (CVCL_0520)

[Text version]
Cell line name SGC-7901
Synonyms SGC 7901; SGC7901
Accession CVCL_0520
Resource Identification Initiative To cite this cell line use: SGC-7901 (RRID:CVCL_0520)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=26116706; PubMed=28851942). Originally thought to originate from the lymph node of a 56 year old female patient with a gastric carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00577.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Proteomics; 2DE-MS.
Omics: Transcriptomics; Microarray.
Miscellaneous: Formerly the CCRID database had 2 entries describing this cell line (3111C0001CCC000236, 3131C0001000700046). They were one of the sources for the STR profile of this entry.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_RK37 (SGC-7901/B1)CVCL_RK36 (SGC-7901/B2)CVCL_VU57 (SGC7901/ADR)
CVCL_B0A1 (SGC7901/OXA)CVCL_VU58 (SGC7901/VCR)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=26116706; PubMed=28851942; PubMed=29717028

Markers:
AmelogeninX
CSF1PO9,10 (PubMed=26116706; PubMed=29717028)
10 (CCRID; PubMed=28851942)
D2S133817
D3S135815,18 (CCRID; PubMed=26116706; PubMed=29717028)
16,18 (PubMed=28851942)
D5S81811,12
D6S104318,19
D7S8208,12 (PubMed=26116706; PubMed=29717028)
12 (CCRID; PubMed=28851942)
D8S117912 (CCRID; PubMed=28851942)
12,13 (PubMed=26116706; PubMed=29717028)
D12S39120,25
D13S31712,13.3 (PubMed=26116706; PubMed=29717028)
13.3 (CCRID; PubMed=28851942)
D16S5399,10
D18S5116
D19S43313 (CCRID; PubMed=28851942)
13,14 (PubMed=26116706; PubMed=29717028)
D21S1127,28
FGA18,21 (CCRID; PubMed=28851942)
21 (PubMed=26116706; PubMed=29717028)
Penta D8,15
Penta E7,17
TH017
TPOX8,12 (PubMed=26116706; PubMed=29717028)
12 (CCRID; PubMed=28851942)
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/gastric-xenograft-model/sgc-7901-xenograft-model/
Publications

DOI=10.1360/sb1982-27-12-1355
Jin-Long Yang, Zu-Ming Shen, Jia-Xian Han;
A study on the biological characteristics of an established human gastric adenocarcinoma cell line (SGC-7901).
Ke Xue Tong Bao 27:1355-1358(1982)

PubMed=6443274; DOI=10.5555/cmj.0366-6999.97.11.p831.01
Chao-Hong Lin, Zhi-Min Fu, Ya-Lun Liu, Jin-Long Yang, Jing-Fang Xu, Qi-San Chen, Hai-Mirg Chen;
Investigation of SGC-7901 cell line established from human gastric carcinoma cells.
Chin. Med. J. 97:831-834(1984)

DOI=10.1007/978-4-431-68252-3_114
Long-Bao Wang, Bo-Wen Qian, Yan-Xing Xia;
Establishment of human gastric cancer cell line (SGC-7901) intraperitoneally transplantable in nude mice.
(In book chapter) Recent advances in management of digestive cancers; Takahashi, Toshio (eds.); pp.416-418; Springer; Tokyo; Japan (1993)

DOI=10.1016/B978-0-12-333530-2.50014-9
Morimasa Sekiguchi, Toshimitsu Suzuki;
Gastric tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.287-316; Academic Press; New York; USA (1994)

PubMed=16038636; DOI=10.1111/j.1745-7254.2005.00149.x
Xiao-Qing Tang, Hu Bi, Jian-Qiang Feng, Jian-Guo Cao;
Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR.
Acta Pharmacol. Sin. 26:1009-1016(2005)

PubMed=16525997; DOI=10.1002/pmic.200402031
Yi-Xuan Yang, Zhi-Qiang Xiao, Zhu-Chu Chen, Gui-Ying Zhang, Hong Yi, Peng-Fei Zhang, Jian-Ling Li, Guo Zhu;
Proteome analysis of multidrug resistance in vincristine-resistant human gastric cancer cell line SGC7901/VCR.
Proteomics 6:2009-2021(2006)

DOI=10.11569/wcjd.v19.i12.1219
Gang Chen, Qing-Rui Wang, Hong Qiu, Shan-Dong Ke, Ying Xiang, Shao-Ming Hu;
Relationship of cellular drug resistance to proportion of side population cells and expression of Mdr1 and ERCC1 in human gastric cell line SGC7901/OXA.
Shi Jie Hua Ren Xiao Hua Za Zhi 19:1219-1224(2011)

PubMed=22576950; DOI=10.1007/s13277-012-0406-3
Ying-Ying Xu, Xiao-Yun Mao, Yong-Xi Song, Feng Zhao, Zhen-Ning Wang, Wei-Xu Zhang, Hui-Mian Xu, Feng Jin;
Midkine confers adriamycin resistance in human gastric cancer cells.
Tumor Biol. 33:1543-1548(2012)

PubMed=26116706; DOI=10.1096/fj.14-266718
Fang Ye, Chu-Guang Chen, Jian Qin, Jie Liu, Cong-Yi Zheng;
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

PubMed=27917905; DOI=10.1038/srep38376; PMCID=PMC5137147
Zhe-Zhou Chen, Wan-Ming Li, Yu Zhang, Min Yu, Lian-Feng Shan, De-Zheng Yuan, Fu-Rong Liu, Jin Fang;
Establishment of a gastric cancer subline with high metastatic potential using a novel microfluidic system.
Sci. Rep. 6:38376-38376(2016)

PubMed=28498440; DOI=10.3892/ijo.2017.3983
Kun Zhuang, Ling-Xia Zhang, Xin Zhang, Hai-Ling Tang, Jun Zhang, Yuan Yan, Kun Han, Han-Qing Guo;
Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901.
Int. J. Oncol. 50:2091-2100(2017)

PubMed=28851942; DOI=10.1038/s41598-017-09660-w; PMCID=PMC5575032
Xiao-Cui Bian, Zhen-Li Yang, Hai-Liang Feng, Hao Sun, Yu-Qin Liu;
A combination of species identification and STR profiling identifies cross-contaminated cells from 482 human tumor cell lines.
Sci. Rep. 7:9774-9774(2017)

PubMed=29717028; DOI=10.1042/BSR20180277; PMCID=PMC6050193
Ye-Qian Zhang, Si-Te Yu, Zi-Zhen Zhang, Gang Zhao, Jia Xu;
Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression.
Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018)

Cross-references
Cell line collections (Providers) CCTCC; GDC0150
Cell line databases/resources MCCL; MCC:0000418
TOKU-E; 3764
Anatomy/cell type resources BTO; BTO_0002392
Chemistry resources ChEMBL-Cells; CHEMBL3307739
ChEMBL-Targets; CHEMBL614909
PubChem_Cell_line; CVCL_0520
Encyclopedic resources Wikidata; Q54953170
Experimental variables resources EFO; EFO_0006293
Gene expression databases GEO; GSM844685
GEO; GSM1374869
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28