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Cellosaurus NCI-H295 (CVCL_0456)

[Text version]
Cell line name NCI-H295
Synonyms H295; H-295; NCI-H-295
Accession CVCL_0456
Resource Identification Initiative To cite this cell line use: NCI-H295 (RRID:CVCL_0456)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10296.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Heterozygous (ATCC=CRL-10296).
Disease Adrenal cortex carcinoma (NCIt: C9325)
Adrenocortical carcinoma (ORDO: Orphanet_1501)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0457 (NCI-H295A)CVCL_0458 (NCI-H295R)CVCL_S901 (NCI-H295R-S2)
CVCL_S902 (NCI-H295R-S3)
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-10296

Markers:
AmelogeninX
CSF1PO10,12
D5S81812
D7S8209,12
D13S31713
D16S53911
TH019.3
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-402.html
Publications

PubMed=2386954
Adi F. Gazdar, Herbert Kazuto Oie, Cedric H. Shackleton, Tchaw-Ren Chen, Timothy J. Triche, Charles E. Myers, George P. Chrousos, Murray Frederick Brennan, Cy A. Stein, Renato V. La Rocca;
Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.
Cancer Res. 50:5488-5496(1990)

PubMed=8404594; DOI=10.1210/endo.133.4.8404594
Ian M. Bird, Neil A. Hanley, Ruth Ann Word, J. Michael Mathis, John L. McCarthy, J. Ian Mason, William E. Rainey;
Human NCI-H295 adrenocortical carcinoma cells: a model for angiotensin-II-responsive aldosterone secretion.
Endocrinology 133:1555-1561(1993)

PubMed=8056157; DOI=10.1016/0303-7207(94)90277-1
William E. Rainey, Ian M. Bird, J. Ian Mason;
The NCI-H295 cell line: a pluripotent model for human adrenocortical studies.
Mol. Cell. Endocrinol. 100:45-50(1994)

PubMed=8806089; DOI=10.1002/jcb.240630502
Adi F. Gazdar, John D. Minna;
NCI series of cell lines: an historical perspective.
J. Cell. Biochem. 63 Suppl. 24:1-11(1996)

PubMed=8806092; DOI=10.1002/jcb.240630505
Ruby M. Phelps, Bruce E. Johnson, Daniel C. Ihde, Adi F. Gazdar, David P. Carbone, Patrick R. McClintock, Ritva Ilona Linnoila, Mary J. Matthews, Paul A. Bunn Jr., Desmond Niall Carney, John D. Minna, James L. Mulshine;
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. Suppl. 24:32-91(1996)

Patent=US5792657
Adi F. Gazdar, Renato V. La Rocca, Cy A. Stein, Charles E. Myers, Herbert Kazuto Oie;
Steroid secreting human adrenocortical carcinoma cell lines.
Patent number US5792657, 11-Aug-1998

PubMed=15541570; DOI=10.1016/j.mce.2003.12.020
William E. Rainey, Karla Saner, Bernard P. Schimmer;
Adrenocortical cell lines.
Mol. Cell. Endocrinol. 228:23-38(2004)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=21924324; DOI=10.1016/j.mce.2011.08.041; PMCID=PMC3288152
Tao Wang, William E. Rainey;
Human adrenocortical carcinoma cell lines.
Mol. Cell. Endocrinol. 351:58-65(2012)

PubMed=22266826; DOI=10.1055/s-0031-1298019; PMCID=PMC4269336
Tao Wang, Jennifer G. Rowland, Jeniel Parmar, Maria Nesterova, Tsugio Seki, William E. Rainey;
Comparison of aldosterone production among human adrenocortical cell lines.
Horm. Metab. Res. 44:245-250(2012)

PubMed=35764904; DOI=10.1007/s12020-022-03112-w; PMCID=PMC9385758
Sandra Sigala, Elisa Rossini, Andrea Abate, Mariangela Tamburello, Stefan Richard Bornstein, Constanze Hantel;
An update on adrenocortical cell lines of human origin.
Endocrine 77:432-437(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-10296 - Discontinued
BCRC; 60354
Cell line databases/resources CLO; CLO_0008081
MCCL; MCC:0000502
cancercelllines; CVCL_0456
TOKU-E; 2687
Anatomy/cell type resources BTO; BTO_0002587
Biological sample resources BioSample; SAMN03471298
Encyclopedic resources Wikidata; Q28226675
Gene expression databases ArrayExpress; E-MTAB-783
Polymorphism and mutation databases Cosmic; 684682
Cosmic; 908466
Cosmic; 1179076
Cosmic; 2239455
Cosmic; 2364100
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number31