ID   NCI-H295
AC   CVCL_0456
SY   H295; H-295; NCI-H-295
DR   BTO; BTO:0002587
DR   CLO; CLO_0008081
DR   MCCL; MCC:0000502
DR   ArrayExpress; E-MTAB-783
DR   ATCC; CRL-10296
DR   BCRC; 60354
DR   BioSample; SAMN03471298
DR   cancercelllines; CVCL_0456
DR   Cosmic; 684682
DR   Cosmic; 908466
DR   Cosmic; 1179076
DR   Cosmic; 2239455
DR   Cosmic; 2364100
DR   TOKU-E; 2687
DR   Wikidata; Q28226675
RX   Patent=US5792657;
RX   PubMed=2386954;
RX   PubMed=8056157;
RX   PubMed=8404594;
RX   PubMed=8806089;
RX   PubMed=8806092;
RX   PubMed=15541570;
RX   PubMed=20164919;
RX   PubMed=21924324;
RX   PubMed=22266826;
RX   PubMed=35764904;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-402.html
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10296.
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Heterozygous (ATCC=CRL-10296).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Discontinued: ATCC; CRL-10296; true.
CC   Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
ST   Source(s): ATCC=CRL-10296
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 13
ST   D16S539: 11
ST   D5S818: 12
ST   D7S820: 9,12
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C9325; Adrenal cortex carcinoma
DI   ORDO; Orphanet_1501; Adrenocortical carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 29
//
RX   Patent=US5792657;
RA   Gazdar A.F., La Rocca R.V., Stein C.A., Myers C.E., Oie H.K.;
RT   "Steroid secreting human adrenocortical carcinoma cell lines.";
RL   Patent number US5792657, 11-Aug-1998.
//
RX   PubMed=2386954;
RA   Gazdar A.F., Oie H.K., Shackleton C.H., Chen T.-R., Triche T.J.,
RA   Myers C.E., Chrousos G.P., Brennan M.F., Stein C.A., La Rocca R.V.;
RT   "Establishment and characterization of a human adrenocortical
RT   carcinoma cell line that expresses multiple pathways of steroid
RT   biosynthesis.";
RL   Cancer Res. 50:5488-5496(1990).
//
RX   PubMed=8056157; DOI=10.1016/0303-7207(94)90277-1;
RA   Rainey W.E., Bird I.M., Mason J.I.;
RT   "The NCI-H295 cell line: a pluripotent model for human adrenocortical
RT   studies.";
RL   Mol. Cell. Endocrinol. 100:45-50(1994).
//
RX   PubMed=8404594; DOI=10.1210/endo.133.4.8404594;
RA   Bird I.M., Hanley N.A., Word R.A., Mathis J.M., McCarthy J.L.,
RA   Mason J.I., Rainey W.E.;
RT   "Human NCI-H295 adrenocortical carcinoma cells: a model for
RT   angiotensin-II-responsive aldosterone secretion.";
RL   Endocrinology 133:1555-1561(1993).
//
RX   PubMed=8806089; DOI=10.1002/jcb.240630502;
RA   Gazdar A.F., Minna J.D.;
RT   "NCI series of cell lines: an historical perspective.";
RL   J. Cell. Biochem. 63 Suppl. 24:1-11(1996).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
//
RX   PubMed=15541570; DOI=10.1016/j.mce.2003.12.020;
RA   Rainey W.E., Saner K., Schimmer B.P.;
RT   "Adrenocortical cell lines.";
RL   Mol. Cell. Endocrinol. 228:23-38(2004).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=21924324; DOI=10.1016/j.mce.2011.08.041;
RA   Wang T., Rainey W.E.;
RT   "Human adrenocortical carcinoma cell lines.";
RL   Mol. Cell. Endocrinol. 351:58-65(2012).
//
RX   PubMed=22266826; DOI=10.1055/s-0031-1298019;
RA   Wang T., Rowland J.G., Parmar J., Nesterova M., Seki T., Rainey W.E.;
RT   "Comparison of aldosterone production among human adrenocortical cell
RT   lines.";
RL   Horm. Metab. Res. 44:245-250(2012).
//
RX   PubMed=35764904; DOI=10.1007/s12020-022-03112-w;
RA   Sigala S., Rossini E., Abate A., Tamburello M., Bornstein S.R.,
RA   Hantel C.;
RT   "An update on adrenocortical cell lines of human origin.";
RL   Endocrine 77:432-437(2022).
//