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Cellosaurus MT-1 [Human contaminated breast cancer] (CVCL_0441)

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Cell line name MT-1 [Human contaminated breast cancer]
Accession CVCL_0441
Resource Identification Initiative To cite this cell line use: MT-1 [Human contaminated breast cancer] (RRID:CVCL_0441)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a breast carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00148.
Population: African American.
Doubling time: 42.4 +- 6.0 hours (PubMed=9150904).
Microsatellite instability: Stable (MSS) (PubMed=12661003; PubMed=15677628).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; Pawefish; -; https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/MT-1.html
Publications

PubMed=1446057; DOI=10.1007/BF01831480
Helga Naundorf, E.C. Rewasowa, Iduna Fichtner, Britta Buttner, Michael Becker, Max Gorlich;
Characterization of two human mammary carcinomas, MT-1 and MT-3, suitable for in vivo testing of ether lipids and their derivatives.
Breast Cancer Res. Treat. 23:87-95(1992)

PubMed=9150904; DOI=10.1023/A:1005756632293
Richard J. Hambly, John A. Double, Michael J. Thompson, Michael C. Bibby;
Establishment and characterisation of new cell lines from human breast tumours initially established as tumour xenografts in NMRI nude mice.
Breast Cancer Res. Treat. 43:247-258(1997)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
Roderick A.F. MacLeod, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Maren Kaufmann, Herbert Milch, Hans Gunther Drexler;
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=11044355; DOI=10.1054/bjoc.2000.1458; PMCID=PMC2408781
Jeffrey M. Davidson, Kylie Louise Gorringe, Suet-Feung Chin, Beatrice Orsetti, C. Besret, Celine Courtay-Cahen, Ian Roberts, Charles Theillet, Carlos Caldas, Paul A.W. Edwards;
Molecular cytogenetic analysis of breast cancer cell lines.
Br. J. Cancer 83:1309-1317(2000)

PubMed=12661003; DOI=10.1002/gcc.10196
Susanne Seitz, Peter Wassmuth, Jens Plaschke, Hans Konrad Schackert, Uwe Karsten, Mauro F. Santibanez-Koref, Peter Michael Schlag, Siegfried Scherneck;
Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.
Genes Chromosomes Cancer 37:29-35(2003)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Kylie Louise Gorringe, Suet-Feung Chin, Paul D.P. Pharoah, Joanne M. Staines, Carla Oliveira, Paul A.W. Edwards, Carlos Caldas;
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources MCCL; MCC:0000337
Biological sample resources BioSample; SAMN03151746
Encyclopedic resources Wikidata; Q54906927
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25