ID   MT-1 [Human contaminated breast cancer]
AC   CVCL_0441
DR   MCCL; MCC:0000337
DR   BioSample; SAMN03151746
DR   Wikidata; Q54906927
RX   PubMed=1446057;
RX   PubMed=9150904;
RX   PubMed=10508494;
RX   PubMed=11044355;
RX   PubMed=12661003;
RX   PubMed=15677628;
RX   PubMed=20143388;
WW   https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/MT-1.html
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a breast carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00148.
CC   Population: African American.
CC   Doubling time: 42.4 +- 6.0 hours (PubMed=9150904).
CC   Microsatellite instability: Stable (MSS) (PubMed=12661003; PubMed=15677628).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
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RX   PubMed=1446057; DOI=10.1007/BF01831480;
RA   Naundorf H., Rewasowa E.C., Fichtner I., Buttner B., Becker M.,
RA   Gorlich M.;
RT   "Characterization of two human mammary carcinomas, MT-1 and MT-3,
RT   suitable for in vivo testing of ether lipids and their derivatives.";
RL   Breast Cancer Res. Treat. 23:87-95(1992).
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RX   PubMed=9150904; DOI=10.1023/A:1005756632293;
RA   Hambly R.J., Double J.A., Thompson M.J., Bibby M.C.;
RT   "Establishment and characterisation of new cell lines from human
RT   breast tumours initially established as tumour xenografts in NMRI nude
RT   mice.";
RL   Breast Cancer Res. Treat. 43:247-258(1997).
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RX   PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2;
RA   MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H.,
RA   Drexler H.G.;
RT   "Widespread intraspecies cross-contamination of human tumor cell lines
RT   arising at source.";
RL   Int. J. Cancer 83:555-563(1999).
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RX   PubMed=11044355; DOI=10.1054/bjoc.2000.1458;
RA   Davidson J.M., Gorringe K.L., Chin S.-F., Orsetti B., Besret C.,
RA   Courtay-Cahen C., Roberts I., Theillet C., Caldas C., Edwards P.A.W.;
RT   "Molecular cytogenetic analysis of breast cancer cell lines.";
RL   Br. J. Cancer 83:1309-1317(2000).
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RX   PubMed=12661003; DOI=10.1002/gcc.10196;
RA   Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U.,
RA   Santibanez-Koref M.F., Schlag P.M., Scherneck S.;
RT   "Identification of microsatellite instability and mismatch repair gene
RT   mutations in breast cancer cell lines.";
RL   Genes Chromosomes Cancer 37:29-35(2003).
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RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
RA   Gorringe K.L., Chin S.-F., Pharoah P.D.P., Staines J.M., Oliveira C.,
RA   Edwards P.A.W., Caldas C.;
RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
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RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
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