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Cellosaurus HL-1 (CVCL_0303)

[Text version]
Cell line name HL-1
Synonyms HL1; HL-1 F2 P76
Accession CVCL_0303
Resource Identification Initiative To cite this cell line use: HL-1 (RRID:CVCL_0303)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12197.
Characteristics: From transgenic mice expressing a fusion gene comprised of the atrial natriuretic factor promoter and the SV40 early region.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from sampling site: Heart; left atrium. Cell type=Cardiomyocyte.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3HeB/FeJ transgenic.
Originate from same individual CVCL_JK52 ! AT-1 [Mouse cardiomyocyte]
Sex of cell Female
Category Transformed cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-549.html

PubMed=9501201; DOI=10.1073/pnas.95.6.2979
Claycomb W.C., Lanson N.A. Jr., Stallworth B.S., Egeland D.B., Delcarpio J.B., Bahinski A., Izzo N.J. Jr.
HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte.
Proc. Natl. Acad. Sci. U.S.A. 95:2979-2984(1998)

PubMed=10908350; DOI=10.1093/nar/28.15.2882
Lanson N.A. Jr., Egeland D.B., Royals B.A., Claycomb W.C.
The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes.
Nucleic Acids Res. 28:2882-2892(2000)

Claycomb W.C.
Mouse cardiac muscle cell line, HL-1.
Patent number US6316207, 13-Nov-2001

PubMed=14766671; DOI=10.1152/ajpheart.00986.2003
White S.M., Constantin P.E., Claycomb W.C.
Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function.
Am. J. Physiol. Heart Circ. Physiol. 286:H823-H829(2004)

Cell line collections Millipore; SCC065
Cell line databases/resources MCCL; MCC:0000194
Lonza; 740
Anatomy/cell type resources BTO; BTO:0003264
Encyclopedic resources Wikidata; Q29838237
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number18