ID   HL-1
AC   CVCL_0303
SY   HL1; HL-1 F2 P76
DR   BTO; BTO:0003264
DR   MCCL; MCC:0000194
DR   Lonza; 740
DR   Millipore; SCC065
DR   Ubigene; YC-C100
DR   Wikidata; Q29838237
RX   Patent=US6316207;
RX   PubMed=9501201;
RX   PubMed=10908350;
RX   PubMed=14766671;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12197.
CC   Characteristics: Spontaneously contract while maintaining a differentiated cardiac phenotype (Millipore=SCC065).
CC   Characteristics: From transgenic mice expressing a fusion gene comprised of the atrial natriuretic factor promoter and the SV40 early region.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Caution: The STR profile of HL-1 as distributed from Ubigene shows that the cell line that what they distribute is not HL-1 but C2C12 (Cellosaurus=CVCL_0188) or a derivative of that cell line (Ubigene=YC-C100).
CC   Derived from site: In situ; Heart, left atrium; UBERON=UBERON_0002079.
CC   Cell type: Cardiomyocyte; CL=CL_0002495.
CC   Breed/subspecies: C3HeB/FeJ transgenic.
ST   Source(s): Millipore=SCC065
ST   Mouse STR 1-1: 17
ST   Mouse STR 1-2: 19
ST   Mouse STR 11-2: 16
ST   Mouse STR 12-1: 16,17
ST   Mouse STR 13-1: 17
ST   Mouse STR 15-3: 21.3
ST   Mouse STR 17-2: 15
ST   Mouse STR 18-3: 16
ST   Mouse STR 19-2: 13
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 14
ST   Mouse STR 4-2: 20.3
ST   Mouse STR 5-5: 17,18
ST   Mouse STR 6-4: 18
ST   Mouse STR 6-7: 12,17
ST   Mouse STR 7-1: 26.2
ST   Mouse STR 8-1: 16
ST   Mouse STR X-1: 28
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
OI   CVCL_JK52 ! AT-1 [Mouse cardiomyocyte]
SX   Female
AG   Age unspecified
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 21
RX   Patent=US6316207;
RA   Claycomb W.C.;
RT   "Mouse cardiac muscle cell line, HL-1.";
RL   Patent number US6316207, 13-Nov-2001.
RX   PubMed=9501201; DOI=10.1073/pnas.95.6.2979;
RA   Claycomb W.C., Lanson N.A. Jr., Stallworth B.S., Egeland D.B.,
RA   Delcarpio J.B., Bahinski A., Izzo N.J. Jr.;
RT   "HL-1 cells: a cardiac muscle cell line that contracts and retains
RT   phenotypic characteristics of the adult cardiomyocyte.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:2979-2984(1998).
RX   PubMed=10908350; DOI=10.1093/nar/28.15.2882;
RA   Lanson N.A. Jr., Egeland D.B., Royals B.A., Claycomb W.C.;
RT   "The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T
RT   antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes.";
RL   Nucleic Acids Res. 28:2882-2892(2000).
RX   PubMed=14766671; DOI=10.1152/ajpheart.00986.2003;
RA   White S.M., Constantin P.E., Claycomb W.C.;
RT   "Cardiac physiology at the cellular level: use of cultured HL-1
RT   cardiomyocytes for studies of cardiac muscle cell structure and
RT   function.";
RL   Am. J. Physiol. Heart Circ. Physiol. 286:H823-H829(2004).