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Cellosaurus G-401 (CVCL_0270)

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Cell line name G-401
Synonyms G401; G 401
Accession CVCL_0270
Resource Identification Initiative To cite this cell line use: G-401 (RRID:CVCL_0270)
Comments Problematic cell line: Misclassified. Originally thought to be a Wilms tumor cell line but is a kidney rhabdoid tumor cell line (PubMed=8382007; PubMed=30924592).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.48
Native American0.75
East Asian, North2.12
East Asian, South0.55
South Asian8.63
European, North29.24
European, South56.23
Disease Rhabdoid tumor of the kidney (NCIt: C8715)
Rhabdoid tumor (ORDO: Orphanet_69077)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_QW55 (G-401 BAF47)CVCL_J252 (G-401-Luc)CVCL_L269 (G401.6)
Sex of cell Male
Age at sampling 3M
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1441; CCRID=1101HUM-PUMC000034; Cosmic-CLP=907299; ECACC=87042204; JCRB=JCRB9065; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11,13
D2S133818,24
D3S135816,18
D5S81813
D7S82011,14
D8S117913,14
D13S3179,14
D16S53912
D18S5114
D19S43313,14
D21S1131,32.2 (CCRID=1101HUM-PUMC000034)
31,32.2,33.2 (ATCC=CRL-1441; PubMed=25877200)
FGA24,26,27 (ATCC=CRL-1441)
24,27 (CCRID=1101HUM-PUMC000034; PubMed=25877200)
Penta D10,11
Penta E7
TH018,9.3 (ATCC=CRL-1441; CCRID=1101HUM-PUMC000034; Cosmic-CLP=907299; ECACC=87042204; JCRB=JCRB9065)
9.3 (PubMed=25877200)
TPOX8,11 (ATCC=CRL-1441; CCRID=1101HUM-PUMC000034; Cosmic-CLP=907299; ECACC=87042204; JCRB=JCRB9065)
11 (PubMed=25877200)
vWA16

Run an STR similarity search on this cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/g/cell-lines-detail-286.html
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/kidney-cancer-xenograft/g401-xenograft-model/
Publications

PubMed=8382007; PMCID=PMC1886739
Abbott Julian Garvin, Gian G. Re, Betty I. Tarnowski, Debra J. Hazen-Martin, Donald A. Sens;
The G401 cell line, utilized for studies of chromosomal changes in Wilms' tumor, is derived from a rhabdoid tumor of the kidney.
Am. J. Pathol. 142:375-380(1993)

PubMed=9671307; DOI=10.1038/28212
Isabella Versteege, Nicolas Sevenet, Julian Lange, Marie-Francoise Rousseau-Merck, Peter F. Ambros, Rupert Handgretinger, Alain Aurias, Olivier Delattre;
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.
Nature 394:203-206(1998)

PubMed=10397258
Marie-Francoise Rousseau-Merck, Isabella Versteege, Isabelle Legrand, Jerome Couturier, Aline Mairal, Olivier Delattre, Alain Aurias;
hSNF5/INI1 inactivation is mainly associated with homozygous deletions and mitotic recombinations in rhabdoid tumors.
Cancer Res. 59:3152-3156(1999)

PubMed=10602515; DOI=10.1038/sj.onc.1203168
Marc F. DeCristofaro, Bryan L. Betz, Wei-Dong Wang, Bernard E. Weissman;
Alteration of hSNF5/INI1/BAF47 detected in rhabdoid cell lines and primary rhabdomyosarcomas but not Wilms' tumors.
Oncogene 18:7559-7565(1999)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Beverly A. Teicher, Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly ...Show all 14 authors... , Erik Harris, Anne Monks, Joel Morris; Show fewer authors
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28945250; DOI=10.1038/ng.3958; PMCID=PMC5803080
Robert T. Nakayama, John L. Pulice, Alfredo M. Valencia, Matthew J. McBride, Zachary M. McKenzie, Mark A. Gillespie, Wai Lim Ku, Ming-Xiang Teng, Kai-Rong Cui, Robert T. Williams, Seth H. Cassel ...Show all 18 authors... , He Qing, Christian J. Widmer, George Daniel Demetri, Rafael Angel Irizarry, Ke-Ji Zhao, Jeffrey A. Ranish, Cigall Kadoch; Show fewer authors
SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters.
Nat. Genet. 49:1613-1623(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30924592; DOI=10.1002/pbc.27741
Kathy Pritchard-Jones, Daniela Perotti;
WARNING: G-401 and SK-NEP-1 cell lines are not Wilms tumor cell lines.
Pediatr. Blood Cancer 66:e27741.1-e27741.2(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-1441
BCRJ; 0418
ECACC; 87042204
JCRB; JCRB9065
Cell line databases/resources CLO; CLO_0003434
MCCL; MCC:0000161
CLDB; cl1409
cancercelllines; CVCL_0270
CCRID; 1101HUM-PUMC000034
Cell_Model_Passport; SIDM00856
Cosmic-CLP; 907299
DepMap; ACH-000096
IGRhCellID; G401
LINCS_LDP; LCL-1511
TOKU-E; 1303
Anatomy/cell type resources BTO; BTO_0002586
Biological sample resources 4DN; 4DNSR6XERO32
BioSample; SAMN03470969
BioSample; SAMN03472819
BioSample; SAMN10987919
ENCODE; ENCBS062JBT
ENCODE; ENCBS432GBV
ENCODE; ENCBS629BMK
ENCODE; ENCBS659PBH
Chemistry resources ChEMBL-Cells; CHEMBL3308394
ChEMBL-Targets; CHEMBL613509
GDSC; 907299
PharmacoDB; G401_374_2019
PubChem_Cell_line; CVCL_0270
Encyclopedic resources Wikidata; Q54835347
Experimental variables resources EFO; EFO_0002179
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10809-111A8
GEO; GSM827165
GEO; GSM887017
GEO; GSM888086
GEO; GSM1669799
GEO; GSM1676299
GEO; GSM1701634
GEO; GSM2033123
GEO; GSM2033124
GEO; GSM2033125
GEO; GSM2033126
GEO; GSM2033127
GEO; GSM2033128
GEO; GSM2409659
GEO; GSM2409660
GEO; GSM2409661
GEO; GSM2409662
GEO; GSM2409663
GEO; GSM2495985
GEO; GSM2787352
Polymorphism and mutation databases Cosmic; 683682
Cosmic; 802044
Cosmic; 802245
Cosmic; 907299
IARC_TP53; 21334
LiGeA; CCLE_546
Progenetix; CVCL_0270
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number45