ID   G-401
AC   CVCL_0270
SY   G401; G 401
DR   BTO; BTO_0002586
DR   CLO; CLO_0003434
DR   EFO; EFO_0002179
DR   MCCL; MCC:0000161
DR   CLDB; cl1409
DR   4DN; 4DNSR6XERO32
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1441
DR   BCRJ; 0418
DR   BioSample; SAMN03470969
DR   BioSample; SAMN03472819
DR   BioSample; SAMN10987919
DR   cancercelllines; CVCL_0270
DR   CCRID; 1101HUM-PUMC000034
DR   Cell_Model_Passport; SIDM00856
DR   ChEMBL-Cells; CHEMBL3308394
DR   ChEMBL-Targets; CHEMBL613509
DR   Cosmic; 683682
DR   Cosmic; 802044
DR   Cosmic; 802245
DR   Cosmic; 907299
DR   Cosmic-CLP; 907299
DR   DepMap; ACH-000096
DR   ECACC; 87042204
DR   EGA; EGAS00001000978
DR   ENCODE; ENCBS062JBT
DR   ENCODE; ENCBS432GBV
DR   ENCODE; ENCBS629BMK
DR   ENCODE; ENCBS659PBH
DR   FANTOM5_SSTAR; 10809-111A8
DR   GDSC; 907299
DR   GEO; GSM827165
DR   GEO; GSM887017
DR   GEO; GSM888086
DR   GEO; GSM1669799
DR   GEO; GSM1676299
DR   GEO; GSM1701634
DR   GEO; GSM2033123
DR   GEO; GSM2033124
DR   GEO; GSM2033125
DR   GEO; GSM2033126
DR   GEO; GSM2033127
DR   GEO; GSM2033128
DR   GEO; GSM2409659
DR   GEO; GSM2409660
DR   GEO; GSM2409661
DR   GEO; GSM2409662
DR   GEO; GSM2409663
DR   GEO; GSM2495985
DR   GEO; GSM2787352
DR   IARC_TP53; 21334
DR   IGRhCellID; G401
DR   JCRB; JCRB9065
DR   LiGeA; CCLE_546
DR   LINCS_LDP; LCL-1511
DR   PharmacoDB; G401_374_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0270
DR   PubChem_Cell_line; CVCL_0270
DR   TOKU-E; 1303
DR   Wikidata; Q54835347
RX   PubMed=8382007;
RX   PubMed=9671307;
RX   PubMed=10397258;
RX   PubMed=10602515;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=25877200;
RX   PubMed=26351324;
RX   PubMed=27397505;
RX   PubMed=28945250;
RX   PubMed=30894373;
RX   PubMed=30924592;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=35839778;
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/g/cell-lines-detail-286.html
WW   Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/kidney-cancer-xenograft/g401-xenograft-model/
CC   Problematic cell line: Misclassified. Originally thought to be a Wilms tumor cell line but is a kidney rhabdoid tumor cell line (PubMed=8382007; PubMed=30924592).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene deletion; HGNC; HGNC:11103; SMARCB1; Zygosity=Homozygous (PubMed=9671307; PubMed=10602515; PubMed=28945250).
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Omics: Genomics; ChIP-seq; H3K27me3.
CC   Omics: Genomics; ChIP-seq; H3K4me3.
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=2.48%; Native American=0.75%; East Asian, North=2.12%; East Asian, South=0.55%; South Asian=8.63%; European, North=29.24%; European, South=56.23% (PubMed=30894373).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): ATCC=CRL-1441; CCRID=1101HUM-PUMC000034; Cosmic-CLP=907299; ECACC=87042204; JCRB=JCRB9065; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D13S317: 9,14
ST   D16S539: 12
ST   D18S51: 14
ST   D19S433: 13,14
ST   D21S11: 31,32.2 (CCRID=1101HUM-PUMC000034)
ST   D21S11: 31,32.2,33.2 (ATCC=CRL-1441; PubMed=25877200)
ST   D2S1338: 18,24
ST   D3S1358: 16,18
ST   D5S818: 13
ST   D7S820: 11,14
ST   D8S1179: 13,14
ST   FGA: 24,26,27 (ATCC=CRL-1441)
ST   FGA: 24,27 (CCRID=1101HUM-PUMC000034; PubMed=25877200)
ST   Penta D: 10,11
ST   Penta E: 7
ST   TH01: 8,9.3 (ATCC=CRL-1441; CCRID=1101HUM-PUMC000034; Cosmic-CLP=907299; ECACC=87042204; JCRB=JCRB9065)
ST   TH01: 9.3 (PubMed=25877200)
ST   TPOX: 8,11 (ATCC=CRL-1441; CCRID=1101HUM-PUMC000034; Cosmic-CLP=907299; ECACC=87042204; JCRB=JCRB9065)
ST   TPOX: 11 (PubMed=25877200)
ST   vWA: 16
DI   NCIt; C8715; Rhabdoid tumor of the kidney
DI   ORDO; Orphanet_69077; Rhabdoid tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   3M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 45
CH   CVCL_QW55 ! G-401 BAF47
CH   CVCL_J252 ! G-401-Luc
CH   CVCL_L269 ! G401.6
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=30924592; DOI=10.1002/pbc.27741;
RA   Pritchard-Jones, Kathryn
RA   Perotti, Daniela
RT   "WARNING: G-401 and SK-NEP-1 cell lines are not Wilms tumor cell
RT   lines.";
RL   Pediatr. Blood Cancer 66:e27741.1-e27741.2(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=8382007; PMCID=PMC1886739;
RA   Garvin, Abbott Julian
RA   Re, Gian G.
RA   Tarnowski, Betty I.
RA   Hazen-Martin, Debra J.
RA   Sens, Donald A.
RT   "The G401 cell line, utilized for studies of chromosomal changes in
RT   Wilms' tumor, is derived from a rhabdoid tumor of the kidney.";
RL   Am. J. Pathol. 142:375-380(1993).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476;
RA   Teicher, Beverly A.
RA   Polley, Eric C.
RA   Kunkel, Mark W.
RA   Evans, David
RA   Silvers, Thomas E.
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Selby, Michael
RA   Connelly, John
RA   Harris, Erik
RA   Monks, Anne
RA   Morris, Joel
RT   "Sarcoma cell line screen of oncology drugs and investigational agents
RT   identifies patterns associated with gene and microRNA expression.";
RL   Mol. Cancer Ther. 14:2452-2462(2015).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=9671307; DOI=10.1038/28212;
RA   Versteege, Isabella
RA   Sevenet, Nicolas
RA   Lange, Julian
RA   Rousseau-Merck, Marie-Francoise
RA   Ambros, Peter F.
RA   Handgretinger, Rupert
RA   Aurias, Alain
RA   Delattre, Olivier
RT   "Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.";
RL   Nature 394:203-206(1998).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254;
RA   Nusinow, David Paul
RA   Szpyt, John
RA   Ghandi, Mahmoud
RA   Rose, Christopher M.
RA   McDonald, E. Robert 3rd
RA   Kalocsay, Marian
RA   Jane-Valbuena, Judit
RA   Gelfand, Ellen T.
RA   Schweppe, Devin Karl
RA   Jedrychowski, Mark P.
RA   Golji, Javad
RA   Porter, Dale A.
RA   Rejtar, Tomas
RA   Wang, Y. Karen
RA   Kryukov, Gregory V.
RA   Stegmeier, Frank
RA   Erickson, Brian K.
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RA   Gygi, Steven P.
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//
RX   PubMed=10397258;
RA   Rousseau-Merck, Marie-Francoise
RA   Versteege, Isabella
RA   Legrand, Isabelle
RA   Couturier, Jerome
RA   Mairal, Aline
RA   Delattre, Olivier
RA   Aurias, Alain
RT   "hSNF5/INI1 inactivation is mainly associated with homozygous
RT   deletions and mitotic recombinations in rhabdoid tumors.";
RL   Cancer Res. 59:3152-3156(1999).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=10602515; DOI=10.1038/sj.onc.1203168;
RA   DeCristofaro, Marc F.
RA   Betz, Bryan L.
RA   Wang, Wei-Dong
RA   Weissman, Bernard E.
RT   "Alteration of hSNF5/INI1/BAF47 detected in rhabdoid cell lines and
RT   primary rhabdomyosarcomas but not Wilms' tumors.";
RL   Oncogene 18:7559-7565(1999).
//
RX   PubMed=28945250; DOI=10.1038/ng.3958; PMCID=PMC5803080;
RA   Nakayama, Robert T.
RA   Pulice, John L.
RA   Valencia, Alfredo M.
RA   McBride, Matthew J.
RA   McKenzie, Zachary M.
RA   Gillespie, Mark A.
RA   Ku, Wai Lim
RA   Teng, Ming-Xiang
RA   Cui, Kai-Rong
RA   Williams, Robert T.
RA   Cassel, Seth H.
RA   Qing, He
RA   Widmer, Christian J.
RA   Demetri, George Daniel
RA   Irizarry, Rafael Angel
RA   Zhao, Ke-Ji
RA   Ranish, Jeffrey A.
RA   Kadoch, Cigall
RT   "SMARCB1 is required for widespread BAF complex-mediated activation of
RT   enhancers and bivalent promoters.";
RL   Nat. Genet. 49:1613-1623(2017).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//