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Cellosaurus CC-LP-1 (CVCL_0205)

[Text version]
Cell line name CC-LP-1
Synonyms CC-LP-I; CCLP-1; CCLP1
Accession CVCL_0205
Resource Identification Initiative To cite this cell line use: CC-LP-1 (RRID:CVCL_0205)
Comments Part of: Biliary tract cancer cell line atlas.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 180 hours (PubMed=1355757).
Caution: Indicated to derive from a female patient in PubMed=1355757, but has a X,Y amelogenin STR marker.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly34Val (c.101G>T); ClinVar=VCV000017582; Zygosity=Unspecified (DepMap=ACH-001959).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (DepMap=ACH-001959).
Disease Intrahepatic cholangiocarcinoma (NCIt: C35417)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001959

Markers:
AmelogeninX,Y
CSF1PO11,13
D3S135815,16
D5S81811,12
D7S82010,11
D8S117911,13
D13S3179,12
D16S5399,13
D18S5113,14
D21S1129,33
FGA22
Penta D12,13
Penta E12
TH019.3
TPOX8,11
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=1355757; DOI=10.1002/ijc.2910520217
Yukihiro Shimizu, Anthony Jacob Demetris, Susanne M. Gollin, Patrick Daniel Storto, H. Melanie Bedford, Silvio Altarac, Shunzaburo Iwatsuki, Ronald Bruce Herberman, Theresa L. Whiteside;
Two new human cholangiocarcinoma cell lines and their cytogenetics and responses to growth factors, hormones, cytokines or immunologic effector cells.
Int. J. Cancer 52:252-260(1992)

CLPUB00275
Sebastian Zach, Emrullah Birgin, Felix Ruckert;
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442; PMCID=PMC5458737
Supriya Kumar Saha, John D. Gordan, Benjamin P. Kleinstiver, Phuong Vu, Mortada S. Najem, Jia-Chi Yeo, Lei Shi, Yasutaka Kato, Rebecca S. Levin, James T. Webber, Leah J. Damon ...Show all 28 authors... , Regina K. Egan, Patricia Greninger, Ultan McDermott, Mathew J. Garnett, Roger L. Jenkins, Kimberly M. Rieger-Christ, Travis B. Sullivan, Aram Francis Hezel, Andrew S. Liss, Yusuke Mizukami, Lipika Goyal, Cristina Rosa Ferrone, Andrew Xiu-Xuan Zhu, Jae Keith Joung, Kevan Michael Shokat, Cyril Henri Benes, Nabeel M. Bardeesy; Show fewer authors
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=31109923; DOI=10.1158/2159-8290.CD-19-0182; PMCID=PMC6677584
Lipika Goyal, Lei Shi, Leah Y. Liu, Ferran Fece de la Cruz, Jochen K. Lennerz, Srivatsan Raghavan, Ignaty Leschiner, Liudmila Elagina, Giulia Siravegna, Raymond W.S. Ng, Phuong Vu ...Show all 42 authors... , Krushna C. Patra, Supriya Kumar Saha, Raul N. Uppot, Ronald Steven Arellano, Stephanie Reyes, Takeshi Sagara, Sachie Otsuki, Brandon Nadres, Heather A. Shahzade, Ipsita Dey-Guha, Isobel J. Fetter, Islam Baiev, Emily E. Van Seventer, Janet Elaine Murphy, Cristina Rosa Ferrone, Kenneth K. Tanabe, Vikram Deshpande, James J. Harding, Rona D. Yaeger, Robin Kate Kelley, Alberto Bardelli, Anthony John Iafrate, William Chun Hahn, Cyril Henri Benes, David Tsai Ting, Hiroshi Hirai, Gad Getz, Dejan Juric, Andrew Xiu-Xuan Zhu, Ryan Bruce Corcoran, Nabeel M. Bardeesy; Show fewer authors
TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma.
Cancer Discov. 9:1064-1079(2019)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Abdulkadir Isidan, Ali Yenigun, Daiki Soma, Eric Aksu, Kevin Lopez, Yujin Park, Arthur Cross-Najafi, Ping Li, Debjyoti Kundu, Michael G. House, Sanjukta Chakraborty ...Show all 17 authors... , Shannon Glaser, Lindsey Kennedy, Heather Francis, Wen-Jun Zhang, Gianfranco D. Alpini, Burcin Ekser; Show fewer authors
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448
Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, Prabhat Kattel, Lauren Kenney, Joshua Merritt, Ramzi Adil, Qi-Biao Wu, Yuan-Li Zhen ...Show all 39 authors... , Robert Morris, Johannes Kreuzer, Meena Kathiresan, Xcanda Ixchel Herrera Lopez, Haley Ellis, Ilaria G. Gritti, Lilian Lecorgne, Ines Farag, Alexandra Popa, William Shen, Hiroyuki Kato, Qin Xu, Eranga Roshan Balasooriya, Meng-Ju Wu, Saireudee Chaturantabut, Robin Kate Kelley, James Mark Cleary, Michael Scott Lawrence, David E. Root, Cyril Henri Benes, Vikram Deshpande, Dejan Juric, William Raj Sellers, Cristina Rosa Ferrone, Wilhelm Haas, Francisca Vazquez, Gad Getz, Nabeel M. Bardeesy; Show fewer authors
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
bioRxiv 2024:07.04.601970-07.04.601970(2024)

Cross-references
Cell line databases/resources MCCL; MCC:0000094
cancercelllines; CVCL_0205
Cell_Model_Passport; SIDM01889
DepMap; ACH-001959
TOKU-E; 4041
Anatomy/cell type resources BTO; BTO_0002933
Encyclopedic resources Wikidata; Q54808710
Polymorphism and mutation databases Cosmic; 927189
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number23