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Cellosaurus SiHa (CVCL_0032)

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Cell line name SiHa
Synonyms Siha; SIHA
Accession CVCL_0032
Resource Identification Initiative To cite this cell line use: SiHa (RRID:CVCL_0032)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Human Protein Atlas, Cell Atlas panel.
Population: Japanese.
Virology: Contains a complete HPV16 genome with a disruption of the E2 region and a small deletion (PubMed=24201445).
Doubling time: 2.6 days (PubMed=29156801); 17 hours (Note=In 10% FBS), 21 hours (Note=In 5% FBS) (PubMed=30760827).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Secretome; 2DE-MS.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*40:02,40:02
HLA-CC*03:04,03:04
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North84.36
East Asian, South15.4
South Asian0
European, North0
European, South0.24
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D6CM (HyCyte SiHa KO-hFANCD2)CVCL_E6ZA (SiHa fat-1)CVCL_C0TY (SiHa-APOA1)
CVCL_X529 (SiHa-NTRpuro)CVCL_K031 (SiHa/cDDP)CVCL_XB80 (SiHa/VP16)
CVCL_WU75 (TL [Human SiHa contaminated cell line])
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0008002/372; ATCC=HTB-35; CCRID; Cosmic-CLP=930297; KCLB=30035; PubMed=25877200; PubMed=29156801

Markers:
AmelogeninX
CSF1PO12
D2S133824
D3S135816,17
D5S8189
D7S82010
D8S117913,16
D13S31711
D16S5398,12 (PubMed=29156801)
12 (AddexBio=C0008002/372; ATCC=HTB-35; CCRID; Cosmic-CLP=930297; KCLB=30035; PubMed=25877200)
D18S5115
D19S43314.2
D21S1129,31
FGA21
Penta D9,12
Penta E10,12
TH016,9
TPOX8 (AddexBio=C0008002/372; ATCC=HTB-35; CCRID; Cosmic-CLP=930297; KCLB=30035; PubMed=25877200)
8,9 (PubMed=29156801)
vWA14,17

Run an STR similarity search on this cell line
Web pages Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-22.html
Publications

PubMed=5529598; DOI=10.3181/00379727-135-35091a
Friz Friedl, Ikuo Kimura, Toyoro Osato, Yohei Ito;
Studies on a new human cell line (SiHa) derived from carcinoma of uterus. I. Its establishment and morphology.
Proc. Soc. Exp. Biol. Med. 135:543-545(1970)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=2990217; PMCID=PMC1888002
Carole Yee, Indira Krishnan-Hewlett, Carl C. Baker, Richard Schlegel, Peter Maxwell Howley;
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3029430; DOI=10.1128/JVI.61.4.962-971.1987; PMCID=PMC254051
Carl C. Baker, William C. Phelps, Valerie Lindgren, Michael J. Braun, Matthew A. Gonda, Peter Maxwell Howley;
Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines.
J. Virol. 61:962-971(1987)

PubMed=3029760; DOI=10.1073/pnas.84.4.1070; PMCID=PMC304363
Matthias Durst, Carlo Maria Croce, Lutz Gissmann, Elisabeth Schwarz, Kay Huebner;
Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.
Proc. Natl. Acad. Sci. U.S.A. 84:1070-1074(1987)

PubMed=1394225
Kenneth D. Somers, M. Anne Merrick, Martha E. Lopez, Leonard S. Incognito, Gary L. Schechter, Graham Casey;
Frequent p53 mutations in head and neck cancer.
Cancer Res. 52:5997-6000(1992)

PubMed=10423141; DOI=10.1099/0022-1317-80-7-1725
John D. Meissner;
Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines.
J. Gen. Virol. 80:1725-1733(1999)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Stefan E. Baldus, Elisabeth Schwarz, Claudia Lohrey, Marc Zapatka, Stephanie Landsberg, Stephan A. Hahn, Dietmar Schmidt, Hans-Peter Dienes, Wolff Helmut Schmiegel, Irmgard Schwarte-Waldhoff;
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123
Ann-Catrin Andersson, Sara Stromberg, Helena Backvall, Caroline Kampf, Mathias Uhlen, Kenneth Wester, Fredrik Ponten;
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J. Histochem. Cytochem. 54:1413-1423(2006)

PubMed=17311676; DOI=10.1186/1471-2164-8-53; PMCID=PMC1805756
Judith N. Kloth, Jan Oosting, Tom van Wezel, Karoly Szuhai, Jeroen Knijnenburg, Arko Gorter, Gemma G. Kenter, Gert Jan Fleuren, Ekaterina S. Jordanova;
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.
BMC Genomics 8:53.1-53.13(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20429727; DOI=10.3109/02841861003614343
Brita Singers Sorensen, Kasper Toustrup, Michael R. Horsman, Jens Overgaard, Jan Alsner;
Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro.
Acta Oncol. 49:895-905(2010)

PubMed=21439369; DOI=10.1016/j.mcp.2011.03.003
Markus Schmitt, Michael Pawlita;
The HPV transcriptome in HPV16 positive cell lines.
Mol. Cell. Probes 25:108-113(2011)

PubMed=22412903; DOI=10.1371/journal.pone.0032667; PMCID=PMC3296745
Oscar Vazquez-Mena, Ingrid Medina-Martinez, Eligia Juarez-Torres, Valeria Barron, Ana Espinosa, Nicolas Villegas-Sepulveda, Laura Gomez-Laguna, Karem Nieto-Martinez, Lorena Orozco, Edgar Roman-Bassaure, Sergio Munoz Cortez ...Show all 17 authors... , Manuel Borges Ibanez, Carlos Alberto Venegas-Vega, Mariano Guardado-Estrada, Angelica Rangel-Lopez, Susana Kofman, Jaime Berumen; Show fewer authors
Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancer cell lines.
PLoS ONE 7:e32667.1-e32667.17(2012)

PubMed=24134916; DOI=10.1186/1755-8166-6-44; PMCID=PMC3879223
Amanda McCormack, Jiang-Lan Fan, Max Duesberg, Mathew Bloomfield, Christian Fiala, Peter Heinz Duesberg;
Individual karyotypes at the origins of cervical carcinomas.
Mol. Cytogenet. 6:44.1-44.23(2013)

PubMed=23881600; DOI=10.1002/jcp.24433
Maddaly Ravi, Sunil Sah, Rajesh Bhammar;
Differences of SiHa (human cancer of cervix) and BMG-1 (brain glioma) cell lines as 2D and 3D cultures.
J. Cell. Physiol. 229:127-131(2014)

PubMed=24201445; DOI=10.1101/gr.164806.113; PMCID=PMC3912410
Keiko Akagi, Jing-Feng Li, Tatevik R. Broutian, Hesed Maria Padilla-Nash, Wei-Hong Xiao, Bo Jiang, James W. Rocco, Theodoros Null Teknos, Bhavna Kumar, Danny Wangsa, Dan He ...Show all 14 authors... , Thomas Ried, David E. Symer, Maura Lianne Gillison; Show fewer authors
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Genome Res. 24:185-199(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28261610; DOI=10.1155/2017/4180703; PMCID=PMC5316418
Georgia Kontostathi, Jerome Zoidakis, Manousos Makridakis, Vasiliki Lygirou, Georgios Mermelekas, Theofilos Papadopoulos, Konstantinos Vougas, Alexios Vlamis-Gardikas, Peter Drakakis, Dimitrios Loutradis, Antonia Vlahou ...Show all 13 authors... , Nicholas P. Anagnou, Kalliopi I. Pappa; Show fewer authors
Cervical cancer cell line secretome highlights the roles of transforming growth factor-beta-induced protein ig-h3, peroxiredoxin-2, and NRF2 on cervical carcinogenesis.
BioMed Res. Int. 2017:4180703.1-4180703.15(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30760827; DOI=10.1038/s41598-018-38315-7; PMCID=PMC6374403
Marcela Nunes Rosa, Adriane Feijo Evangelista, Leticia Ferro Leal, Cristina Mendes de Oliveira, Viviane Aline Oliveira Silva, Carla Carolina Munari, Fernanda Franco Munari, Graziela de Macedo Matsushita, Ricardo dos Reis, Carlos Eduardo Andrade, Cristiano de Padua Souza, Rui Manuel Reis;
Establishment, molecular and biological characterization of HCB-514: a novel human cervical cancer cell line.
Sci. Rep. 9:1913.1-1913.13(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35198691; DOI=10.1016/j.dib.2022.107919; PMCID=PMC8844217
Ze-Lu Huang, Wei-Jia Kong, Bertrand Jern-Han Wong, Huan-Huan Gao, Tian-Nan Guo, Xian-Ming Liu, Xiao-Xian Du, Lim-Soon Wong, Wilson Wen-Bin Goh;
Proteomic datasets of HeLa and SiHa cell lines acquired by DDA-PASEF and diaPASEF.
Data Brief 41:107919.1-107919.7(2022)

PubMed=35421932; DOI=10.1186/s12885-022-09528-x; PMCID=PMC9009492
Yue He, Su-Bin Han, Yang Liu, Jing-Jing Zhang, Yu-Mei Wu;
Role of APOA1 in the resistance to platinum-based chemotherapy in squamous cervical cancer.
BMC Cancer 22:411.1-411.12(2022)

PubMed=35692560; DOI=10.1080/23723556.2022.2078628; PMCID=PMC9176225
Ma de Lourdes Zuniga-Martinez, Carlos Miguel Lopez-Mendoza, Jared Tenorio-Salazar, Alejandro Manuel Garcia-Carranca, Marco Antonio Cerbon-Cervantes, Luz Eugenia Alcantara-Quintana;
Establishment, authenticity, and characterization of cervical cancer cell lines.
Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0008002/372
ATCC; HTB-35
CCTCC; GDC0110
CLS; 305023
ICLC; HTL98017
IZSLER; BS TCL 112
KCB; KCB 2013026YJ
KCLB; 30035
Cell line databases/resources CLO; CLO_0009017
MCCL; MCC:0000451
CLDB; cl4298
CLDB; cl4299
CLDB; cl4900
cancercelllines; CVCL_0032
CCRID; 1101HUM-PUMC000294
CCRID; 1102HUM-NIFDC00092
CCRID; 3101HUMSCSP5058
CCRID; 3101HUMTCHu113
CCRID; 4201HUM-CCTCC00110
Cell_Model_Passport; SIDM01093
Cosmic-CLP; 930297
DepMap; ACH-000556
IGRhCellID; SiHa
LINCS_LDP; LCL-1542
TOKU-E; 3119
Anatomy/cell type resources BTO; BTO_0002210
Biological sample resources BioSample; SAMN03473215
BioSample; SAMN10989623
CRISP screens repositories BioGRID_ORCS_Cell_line; 1796
Chemistry resources ChEMBL-Cells; CHEMBL3307968
ChEMBL-Targets; CHEMBL612542
GDSC; 930297
PharmacoDB; SiHa_1377_2019
PubChem_Cell_line; CVCL_0032
Encyclopedic resources Wikidata; Q54953470
Experimental variables resources EFO; EFO_0002379
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM113866
GEO; GSM226740
GEO; GSM226876
GEO; GSM253302
GEO; GSM675738
GEO; GSM685444
GEO; GSM722576
GEO; GSM722577
GEO; GSM723057
GEO; GSM723058
GEO; GSM1670422
GEO; GSM1716411
GEO; GSM1716412
GEO; GSM1716413
GEO; GSM1716414
GEO; GSM1716415
GEO; GSM1716416
GEO; GSM1716423
GEO; GSM1716424
GEO; GSM1716425
GEO; GSM1716426
GEO; GSM7701382
Polymorphism and mutation databases Cosmic; 760220
Cosmic; 809229
Cosmic; 846184
Cosmic; 877467
Cosmic; 925356
Cosmic; 928911
Cosmic; 930297
Cosmic; 1019306
Cosmic; 1131517
Cosmic; 1193028
Cosmic; 1201773
Cosmic; 1324212
Cosmic; 1995627
Cosmic; 2301542
Cosmic; 2660193
Cosmic; 2791018
Cosmic; 2816217
IARC_TP53; 21696
Progenetix; CVCL_0032
Proteomic databases PRIDE; PXD001806
PRIDE; PXD005466
PRIDE; PXD029773
PRIDE; PXD030304
PRIDE; PXD030885
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number47