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Cellosaurus TL [Human SiHa contaminated cell line] (CVCL_WU75)

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Cell line name TL [Human SiHa contaminated cell line]
Synonyms Trophoblast-Like
Accession CVCL_WU75
Resource Identification Initiative To cite this cell line use: TL [Human SiHa contaminated cell line] (RRID:CVCL_WU75)
Comments Problematic cell line: Contaminated. Shown to be a Siha derivative (BCRC=60528). Originally thought to originate from the placenta of a 29 year old woman donor.
Population: Japanese.
Doubling time: ~34 hours (PubMed=3581066).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0032 (SiHa)
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
Web pages Info; BCRC; -; https://www.bcrc.firdi.org.tw/attach/2019-05-28/a.pdf
Publications

PubMed=3581066
Chi-Kuan Ho, Hung Chiang, Shuan-Yow Li, Chiou-Chung Yuan, Heung-Tat Ng;
Establishment and characterization of a tumorigenic trophoblast-like cell line from a human placenta.
Cancer Res. 47:3220-3224(1987)

PubMed=11089925; DOI=10.1078/0171-9335-00091
Chi-Kuan Ho, Shu-Ming Chen, Sheng-Yuan Wang;
Ouabain resistance of a human trophoblast cell line is not related to its reactivity to ouabain.
Eur. J. Cell Biol. 79:765-770(2000)

PubMed=11409691; DOI=10.1007/BF02577537
Chi-Kuan Ho, Lo-Chun Au, Ho-Jen Peng, Sheng-Yuan Wang;
Transforming growth factor beta may act as an autocrine-survival-promoting factor for transformed trophoblasts.
In Vitro Cell. Dev. Biol. Anim. 37:245-250(2001)

Cross-references
Cell line collections (Providers) BCRC; 60528 - Discontinued
Encyclopedic resources Wikidata; Q98133362
Entry history
Entry creation05-Jul-2019
Last entry update10-Apr-2025
Version number7