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Cellosaurus NCI-H23/GEM-R (CVCL_ZZ80)

[Text version]
Cell line name NCI-H23/GEM-R
Synonyms H23/GEM-R
Accession CVCL_ZZ80
Resource Identification Initiative To cite this cell line use: NCI-H23/GEM-R (RRID:CVCL_ZZ80)
Comments Population: African American.
Karyotypic information: Has lost chromosome Y (from parent cell line).
Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Gln1919Pro (c.5756A>C); ClinVar=VCV000580726; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Trp332Ter (c.996G>A); ClinVar=VCV000376339; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Met246Ile (c.738G>C); ClinVar=VCV001758655; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1547 (NCI-H23)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=15471562; DOI=10.1111/j.1349-7006.2004.tb03257.x
Achiwa H., Oguri T., Sato S., Maeda H., Niimi T., Ueda R.
Determinants of sensitivity and resistance to gemcitabine: the roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer.
Cancer Sci. 95:753-757(2004)

PubMed=17237272; DOI=10.1158/1535-7163.MCT-06-0529
Oguri T., Bessho Y., Achiwa H., Ozasa H., Maeno K., Maeda H., Sato S., Ueda R.
MRP8/ABCC11 directly confers resistance to 5-fluorouracil.
Mol. Cancer Ther. 6:122-127(2007)

PubMed=18445659; DOI=10.1158/1535-7163.MCT-07-2088
Oguri T., Ozasa H., Uemura T., Bessho Y., Miyazaki M., Maeno K., Maeda H., Sato S., Ueda R.
MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer.
Mol. Cancer Ther. 7:1150-1155(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZZ80
Encyclopedic resources Wikidata; Q102114583
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number6