ID   NCI-H23/GEM-R
AC   CVCL_ZZ80
SY   H23/GEM-R
DR   cancercelllines; CVCL_ZZ80
DR   Wikidata; Q102114583
RX   PubMed=15471562;
RX   PubMed=17237272;
RX   PubMed=18445659;
CC   Population: African American.
CC   Karyotypic information: Has lost chromosome Y (from parent cell line).
CC   Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar).
CC   Sequence variation: Mutation; HGNC; 795; ATM; Simple; p.Gln1919Pro (c.5756A>C); ClinVar=VCV000580726; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Trp332Ter (c.996G>A); ClinVar=VCV000376339; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Met246Ile (c.738G>C); ClinVar=VCV001758655; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1547 ! NCI-H23
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 05-10-23; Version: 6
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RX   PubMed=15471562; DOI=10.1111/j.1349-7006.2004.tb03257.x;
RA   Achiwa H., Oguri T., Sato S., Maeda H., Niimi T., Ueda R.;
RT   "Determinants of sensitivity and resistance to gemcitabine: the roles
RT   of human equilibrative nucleoside transporter 1 and deoxycytidine
RT   kinase in non-small cell lung cancer.";
RL   Cancer Sci. 95:753-757(2004).
//
RX   PubMed=17237272; DOI=10.1158/1535-7163.MCT-06-0529;
RA   Oguri T., Bessho Y., Achiwa H., Ozasa H., Maeno K., Maeda H., Sato S.,
RA   Ueda R.;
RT   "MRP8/ABCC11 directly confers resistance to 5-fluorouracil.";
RL   Mol. Cancer Ther. 6:122-127(2007).
//
RX   PubMed=18445659; DOI=10.1158/1535-7163.MCT-07-2088;
RA   Oguri T., Ozasa H., Uemura T., Bessho Y., Miyazaki M., Maeno K.,
RA   Maeda H., Sato S., Ueda R.;
RT   "MRP7/ABCC10 expression is a predictive biomarker for the resistance
RT   to paclitaxel in non-small cell lung cancer.";
RL   Mol. Cancer Ther. 7:1150-1155(2008).
//