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Cellosaurus HuH-7-END (CVCL_ZW90)

[Text version]
Cell line name HuH-7-END
Synonyms HuH7-HDV-Env-NTCP clone B1
Accession CVCL_ZW90
Resource Identification Initiative To cite this cell line use: HuH-7-END (RRID:CVCL_ZW90)
Comments Population: Japanese.
Characteristics: Transfected with pJC126, a plasmid harboring a 1.1-fold cDNA copy of the HDV antigenome.
Virology: Persistently replicates and secretes hepatitis delta virus (HDV).
Transfected with: HGNC; 10905; SLC10A1.
Transfected with: UniProtKB; P03138; Hepatitis B virus genotype D subtype ayw envelope protein (HBsAg).
Transfected with: UniProtKB; P33967; B.cereus Bsr.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line

PubMed=31292511; DOI=10.1038/s41598-019-46493-1
Ni Y., Zhang Z.-F., Engelskircher L., Verch G., Tu T., Lempp F.A., Urban S.
Generation and characterization of a stable cell line persistently replicating and secreting the human hepatitis delta virus.
Sci. Rep. 9:10021-10021(2019)

Cell line databases/resources cancercelllines; CVCL_ZW90
Encyclopedic resources Wikidata; Q102114176
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number7