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Cellosaurus Reh/EphA3 (CVCL_ZV66)

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Cell line name Reh/EphA3
Synonyms Reh/A3
Accession CVCL_ZV66
Resource Identification Initiative To cite this cell line use: Reh/EphA3 (RRID:CVCL_ZV66)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3387; EPHA3.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:3495; ETV6 + HGNC; HGNC:10471; RUNX1; Name(s)=ETV6-RUNX1, TEL-AML1 (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg173Cys (c.517C>T); ClinVar=VCV000189500; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg181Cys (c.541C>T); ClinVar=VCV000142624; Zygosity=Heterozygous (from parent cell line).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) ETV6-RUNX1 (NCIt: C80334)
B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) (ORDO: Orphanet_585929)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1650 (Reh)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=27922598; DOI=10.1038/leu.2016.371
Sara Charmsaz, Fares Al-Ejeh, Trina M. Yeadon, Kirrilee J. Miller, Fiona M. Smith, Brett William Stringer, Andrew S. Moore, Fook-Thean Lee, Leanne T. Cooper, Chrysanthos Stylianou, Geoffrey Thomas Yarranton ...Show all 15 authors... , John D. Woronicz, Andrew M. Scott, Martin Lackmann, Andrew Wallace Boyd; Show fewer authors
EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia.
Leukemia 31:1779-1787(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZV66
Encyclopedic resources Wikidata; Q98128900
Entry history
Entry creation02-Jul-2020
Last entry update19-Dec-2024
Version number10