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Cellosaurus Reh (CVCL_1650)

[Text version]
Cell line name Reh
Synonyms REH
Accession CVCL_1650
Resource Identification Initiative To cite this cell line use: Reh (RRID:CVCL_1650)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Human Protein Atlas, Cell Atlas panel.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8286.
Doubling time: 34.7 hours (PubMed=8847894); 30 hours (PubMed=25984343); ~50-70 hours (DSMZ=ACC-22).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Phosphorylation; Quantitative.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:3495; ETV6 + HGNC; HGNC:10471; RUNX1; Name(s)=ETV6-RUNX1, TEL-AML1 (PubMed=8704231; PubMed=9067587; PubMed=15843827; PubMed=35354797).
  • Mutation; HGNC; HGNC:7978; NR3C1; Simple; p.Gln527Ter (c.1579C>T) (p.Gln528Ter, c.1582C>T); Zygosity=Homozygous (PubMed=35124168).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg173Cys (c.517C>T); ClinVar=VCV000189500; Zygosity=Homozygous (Cosmic-CLP=909696; DepMap=ACH-000960).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg181Cys (c.541C>T); ClinVar=VCV000142624; Zygosity=Heterozygous (Cosmic-CLP=909696; DepMap=ACH-000960).
HLA typing Source: DSMZCellDive=ACC-22
Class I
HLA-AA*23:01:01,32:01:01
HLA-BB*35:02:01,50:01:01
HLA-CC*04:01:01,06:02:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:02:01,04:01:01
HLA-DQDQA1*05:05:01,05:05:01
DQB1*03:01:01,03:01:01
HLA-DRDRA*01:02:02,01:02:02
DRB1*11:01:01,12:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African21.18
Native American0.09
East Asian, North1.57
East Asian, South2
South Asian1.52
European, North15.6
European, South58.04
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) ETV6-RUNX1 (NCIt: C80334)
B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) (ORDO: Orphanet_585929)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8857 (EU-1)CVCL_0011 (KM-3)CVCL_8462 (NOI-90)
CVCL_ZV66 (Reh/EphA3)CVCL_A049 (WSU-CLL)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0003031/4985; ATCC=CRL-8286; CLS=300320; Cosmic-CLP=909696; DSMZ=ACC-22; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11,12 (AddexBio=C0003031/4985; ATCC=CRL-8286; PubMed=25877200)
12,13 (CLS=300320; Cosmic-CLP=909696; DSMZ=ACC-22)
D2S133820,22
D3S135818
D5S81811,12 (Cosmic-CLP=909696; DSMZ=ACC-22)
11,12,13 (CLS=300320)
11,13 (AddexBio=C0003031/4985; ATCC=CRL-8286; PubMed=25877200)
D7S8209,10,12,13 (CLS=300320)
9,12 (AddexBio=C0003031/4985; ATCC=CRL-8286; Cosmic-CLP=909696; DSMZ=ACC-22; PubMed=25877200)
D8S117913,14,16,17 (CLS=300320)
13,15 (ATCC=CRL-8286; DSMZ=ACC-22; PubMed=25877200)
D13S31710,11,14 (DSMZ=ACC-22)
11,12,13 (CLS=300320)
11,13 (AddexBio=C0003031/4985; ATCC=CRL-8286; PubMed=25877200)
11,14 (Cosmic-CLP=909696)
D16S5399 (AddexBio=C0003031/4985; ATCC=CRL-8286; PubMed=25877200)
9,10,12,13 (CLS=300320)
9,13 (Cosmic-CLP=909696; DSMZ=ACC-22)
D18S5110,11,14 (CLS=300320)
10,14 (ATCC=CRL-8286; PubMed=25877200)
10,14,15 (DSMZ=ACC-22)
D19S43312,14
D21S1127,28,30,31 (DSMZ=ACC-22)
28,29,30,31 (CLS=300320)
28,30 (ATCC=CRL-8286; PubMed=25877200)
FGA13,22,23 (DSMZ=ACC-22)
22,23 (ATCC=CRL-8286; PubMed=25877200)
22,23,24 (CLS=300320)
Penta D9,11 (ATCC=CRL-8286; PubMed=25877200)
9,12 (CLS=300320)
10,11 (DSMZ=ACC-22)
Penta E7,11 (ATCC=CRL-8286; DSMZ=ACC-22; PubMed=25877200)
10,11 (CLS=300320)
TH017 (AddexBio=C0003031/4985; ATCC=CRL-8286; CLS=300320; PubMed=25877200)
7,9 (Cosmic-CLP=909696; DSMZ=ACC-22)
TPOX8
vWA14,15 (AddexBio=C0003031/4985; ATCC=CRL-8286; Cosmic-CLP=909696; PubMed=25877200)
14,15,16 (CLS=300320; DSMZ=ACC-22)

Run an STR similarity search on this cell line
Web pages Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=194778; DOI=10.1016/0014-2964(77)90085-8
Claude Rosenfeld, Antoine Goutner, Anne-Marie Venuat, Claudine Choquet, Jose-Luis Pico, Jean-Francois Dore, Andre Liabeuf, Anne Durandy, Claude Desgranges, Guy Blaudin de The;
An effect human leukaemic cell line: Reh.
Eur. J. Cancer 13:377-379(1977)

PubMed=197411; DOI=10.1038/267841a0
Claude Rosenfeld, Antoine Goutner, Claudine Choquet, Anne-Marie Venuat, Boniface Kayibanda, Jose-Luis Pico, Melvyn Francis Greaves;
Phenotypic characterisation of a unique non-T, non-B acute lymphoblastic leukaemia cell line.
Nature 267:841-843(1977)

DOI=10.1007/BF00204739
Jacques Bertoglio, Catherine Guibout, Jean-Francois Dore, Claude Rosenfeld;
Further characterization of a non-T, non-B acute lymphoblastic leukaemia cell line (Reh). Reactivity with human sera cytotoxic for leukaemia cells.
Cancer Immunol. Immunother. 4:193-196(1978)

PubMed=279400
Georges Lorans, Claude Rosenfeld, Maurice Petitou, Francoise Phan-Dinh-Tuy, Georges Mathe;
Metabolism of proline in a human leukemic lymphoblastoid cell line.
Cancer Res. 38:3950-3953(1978)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3866637
Abbas Sharif, Catherine Driancourt, Martine Billard, Claude Rosenfeld, Yves Goussault, Roland Bourrillon;
In vitro study of the comparative behaviour of a human acute lymphoblastic leukemia cell line and a reference normal cell line towards the effects of a mitogenic lectin.
Cancer Biochem. Biophys. 8:143-152(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Akinobu Nakano, Takayuki Harada, Shigeru Morikawa, Yuzuru Kato;
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=7630190
Mu-Xiang Zhou, Lu-Bing Gu, Charles David James, J. He, Andrew M. Yeager, Stephen D. Smith, Harry W. Findley Jr.;
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608
Mu-Xiang Zhou, Andrew M. Yeager, Stephen D. Smith, Harry W. Findley Jr.;
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood 85:1608-1614(1995)

PubMed=8704231; DOI=10.1182/blood.V88.3.785.785
Do-Hyun Kim, Richard L. Moldwin, Clementine Vignon, Stefan Klaus Bohlander, Yoshimasa Suto, Lisa Giordano, Rajat Gupta, Scott Fears, Giuseppina Nucifora, Janet Davison Rowley, Stephen D. Smith;
TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines.
Blood 88:785-794(1996)

PubMed=8847894
Akiyoshi Tani, Eiji Tatsumi, Fumihiko Nakamura, Shunichi Kumagai, Yoshiyuki Kosaka, Kimihiko Sano, Hajime Nakamura, Ryuichi Amakawa, Hitoshi Ohno;
Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines.
Leukemia 10:1592-1603(1996)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Cord C. Uphoff, Roderick A.F. MacLeod, Sabine A. Denkmann, Todd Robert Golub, Arndt Borkhardt, Johannes W.G. Janssen, Hans Gunther Drexler;
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=9108419; DOI=10.1182/blood.V89.8.2986
Harry W. Findley Jr., Lu-Bing Gu, Andrew M. Yeager, Mu-Xiang Zhou;
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood 89:2986-2993(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Yoshinobu Matsuo, Hans Gunther Drexler;
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

PubMed=9823951; DOI=10.1038/sj.leu.2401198
Mu-Xiang Zhou, Lu-Bing Gu, Andrew M. Yeager, Harry W. Findley Jr.;
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia 12:1756-1763(1998)

PubMed=10490826; DOI=10.1038/sj.onc.1202874
Xin-Yu Fu, Shannon McGrath, Martina P. Pasillas, Shinpei Nakazawa, Mark P. Kamps;
EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.
Oncogene 18:4920-4929(1999)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=14504097; DOI=10.1182/blood-2003-02-0418
Takeshi Taketani, Tomohiko Taki, Kanji Sugita, Yoshiyuki Furuichi, Eiichi Ishii, Ryoji Hanada, Masahiro Tsuchida, Kenichi Sugita, Kohmei Ida, Yasuhide Hayashi;
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Anna K. Hagstrom-Andersson, Patrik Eden, David Lindgren, Jens Nilsson, Carin Lassen, Jesper Heldrup, Magnus Fontes, Ake Borg, Felix Mitelman, Bertil Johansson, Mattias Hoglund, Thoas Fioretos;
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=16523483; DOI=10.1002/gcc.20317
Sharon W. Horsley, Alan Mackay, Marjan Iravani, Kerry Fenwick, Haukur Valgeirsson, Tim J. Dexter, Alan Ashworth, Lyndal Kearney;
Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.
Genes Chromosomes Cancer 45:554-564(2006)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455
Takeshi Inukai, Xiu-Ru Zhang, Takeshi Kameyama, Yukiko Suzuki, Kazuhito Yoshikawa, Itaru Kuroda, Atsushi Nemoto, Koshi Akahane, Hiroki Sato, Kumiko Goi, Kazunori Nakamoto ...Show all 15 authors... , Jun-ichi Hamada, Mitsuhiro Tada, Tetsuya Moriuchi, Kanji Sugita; Show fewer authors
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Am. J. Hematol. 85:535-537(2010)

PubMed=21552520; DOI=10.1371/journal.pone.0019169; PMCID=PMC3084268
Ting-Lei Gu, Julie Nardone, Yi Wang, Marc Loriaux, Judit Villen, Sean A. Beausoleil, Meghan Tucker, Jon M. Kornhauser, Jian-Min Ren, Joan MacNeill, Steven P. Gygi ...Show all 15 authors... , Brian Jay Druker, Michael Charles Heinrich, John Rush, Roberto D. Polakiewicz; Show fewer authors
Survey of activated FLT3 signaling in leukemia.
PLoS ONE 6:e19169.1-e19169.10(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24056532; DOI=10.1101/gr.159913.113; PMCID=PMC3847780
Nicola E. Potter, Luca Ermini, Elli Papaemmanuil, Giovanni Cazzaniga, Gowri Vijayaraghavan, Ian Titley, Anthony Ford, Peter J. Campbell, Lyndal Kearney, Melvyn Francis Greaves;
Single-cell mutational profiling and clonal phylogeny in cancer.
Genome Res. 23:2115-2125(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27922598; DOI=10.1038/leu.2016.371
Sara Charmsaz, Fares Al-Ejeh, Trina M. Yeadon, Kirrilee J. Miller, Fiona M. Smith, Brett William Stringer, Andrew S. Moore, Fook-Thean Lee, Leanne T. Cooper, Chrysanthos Stylianou, Geoffrey Thomas Yarranton ...Show all 15 authors... , John Woronicz, Andrew M. Scott, Martin Lackmann, Andrew Wallace Boyd; Show fewer authors
EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia.
Leukemia 31:1779-1787(2017)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28569787; DOI=10.1038/cddis.2017.249; PMCID=PMC5520907
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Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.
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PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi ...Show all 14 authors... , Takeshi Inukai, Kanji Sugita, Hajime Hosoi; Show fewer authors
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
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Cancer Res. 79:1263-1273(2019)

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Cross-references
Cell line collections (Providers) AddexBio; C0003031/4985
ATCC; CRL-8286
BCRJ; 0321
CLS; 300320
DSMZ; ACC-22
Cell line databases/resources CLO; CLO_0008781
CLO; CLO_0008782
CLDB; cl4132
cancercelllines; CVCL_1650
CCRID; 3101HUMTCHu131
Cell_Model_Passport; SIDM00447
Cosmic-CLP; 909696
DepMap; ACH-000960
DSMZCellDive; ACC-22
LINCS_LDP; LCL-1039
Lonza; 58
Anatomy/cell type resources BTO; BTO_0001163
Biological sample resources BioSample; SAMN03471040
BioSample; SAMN03473380
BioSample; SAMN10988185
CRISP screens repositories BioGRID_ORCS_Cell_line; 1761
Chemistry resources ChEMBL-Cells; CHEMBL3308823
ChEMBL-Targets; CHEMBL2366320
GDSC; 909696
PharmacoDB; REH_1299_2019
PubChem_Cell_line; CVCL_1650
Encyclopedic resources Wikidata; Q29958043
Experimental variables resources EFO; EFO_0022409
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM236802
GEO; GSM236838
GEO; GSM482492
GEO; GSM499514
GEO; GSM499538
GEO; GSM499727
GEO; GSM499733
GEO; GSM887530
GEO; GSM888612
GEO; GSM931330
GEO; GSM931331
GEO; GSM1195448
GEO; GSM1374847
GEO; GSM1670369
GEO; GSM2373798
GEO; GSM2373799
GEO; GSM5137740
GEO; GSM5137741
GEO; GSM7701448
GEO; GSM7701449
Polymorphism and mutation databases Cosmic; 798668
Cosmic; 801720
Cosmic; 909696
Cosmic; 919149
Cosmic; 991551
Cosmic; 994183
Cosmic; 996287
Cosmic; 998706
Cosmic; 999751
Cosmic; 1012114
Cosmic; 1037725
Cosmic; 1067440
Cosmic; 1093790
Cosmic; 1118468
Cosmic; 1130244
Cosmic; 1191700
Cosmic; 1483360
Cosmic; 1524815
Cosmic; 2491075
Cosmic; 2523595
Cosmic; 2649233
IARC_TP53; 21284
IARC_TP53; 28432
LiGeA; CCLE_618
Progenetix; CVCL_1650
Proteomic databases PRIDE; PXD023662
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number49