| Cell line name |
IIICF |
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| Synonyms |
III-CF |
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| Accession |
CVCL_ZT89 |
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| Resource Identification Initiative |
To cite this cell line use: IIICF (RRID:CVCL_ZT89) |
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| Comments |
Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584. |
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| Sequence variations |
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Heterozygous; Note=Impairs TP53 splicing dramatically (PubMed=1467311).
|
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| Disease |
Li-Fraumeni syndrome (NCIt: C3476)
Li-Fraumeni syndrome (ORDO: Orphanet_524) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Children:
|
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| Sex of cell |
Female |
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| Age at sampling |
30-40Y |
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| Category |
Finite cell line |
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| Publications | PubMed=1467311
Sally G. Warneford, Leah J. Witton, Megan L. Townsend, Peter B. Rowe, Roger Robert Reddel, Luciano Dalla-Pozza, Geoff Symonds;
Germ-line splicing mutation of the p53 gene in a cancer-prone family.
Cell Growth Differ. 3:839-846(1992) PubMed=7651392; DOI=10.1128/mcb.15.9.4745; PMCID=PMC230718
Eileen M. Rogan, Tracy M. Bryan, Bharati Hukku, Kenneth MacLean, Andy C.-M. Chang, Elsa L. Moy, Anna Englezou, Sally G. Warneford, Luciano Dalla-Pozza, Roger Robert Reddel;
Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.
Mol. Cell. Biol. 15:4745-4753(1995) PubMed=19935656; DOI=10.1038/nbt.1587
Jeremy David Henson, Ying Cao, Lily I. Huschtscha, Andy C.-M. Chang, Amy Y.M. Au, Hilda A. Pickett, Roger Robert Reddel;
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q98126771
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| Entry history |
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| Entry creation | 02-Jul-2020 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 8 |
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