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Cellosaurus IIICF/a2 (CVCL_4414)

[Text version]
Cell line name IIICF/a2
Synonyms III-CF culture A2
Accession CVCL_4414
Resource Identification Initiative To cite this cell line use: IIICF/a2 (RRID:CVCL_4414)
Comments Caution: Was briefly displayed in Cell Bank Australia under catalog number CBA-0048 but was never intended to be distributed.
Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Hemizygous; Note=Impairs TP53 splicing dramatically (from parent cell line).
Disease Li-Fraumeni syndrome (NCIt: C3476)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_ZT89 (IIICF)
Sex of cell Female
Age at sampling 30-40Y
Category Spontaneously immortalized cell line
Publications

PubMed=22829774; DOI=10.1371/journal.pgen.1002772
Lovejoy C.A., Li W.-D., Reisenweber S., Thongthip S., Bruno J., de Lange T., De S., Petrini J.H.J., Sung P.A., Jasin M., Rosenbluh J., Zwang Y., Weir B.A., Hatton C., Ivanova E.V., MacConaill L.E., Hanna M., Hahn W.C., Lue N.F., Reddel R.R., Jiao Y.-C., Kinzler K.W., Vogelstein B., Papadopoulos N., Meeker A.K.
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
PLoS Genet. 8:E1002772-E1002772(2012)

Cross-references
Encyclopedic resources Wikidata; Q54897434
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number14