Cellosaurus cell line 138MA (CVCL

Cellosaurus 138MA (CVCL_ZT87)

Cross-references
Cell line name	138MA
Synonyms	138 Manchester
Accession	CVCL_ZT87
Resource Identification Initiative	To cite this cell line use: 138MA (RRID:CVCL_ZT87)
Comments	Senescence: Senesces at 47 PDL (PubMed=9649131). Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (PubMed=8794843; PubMed=9018113; PubMed=9649131).
Disease	Li-Fraumeni syndrome (NCIt: C3476) Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_ZT86 ! 21MA
Sex of cell	Male
Age at sampling	16Y
Category	Finite cell line
Publications	PubMed=8794843; DOI=10.1080/095530096145139 Sproston A.R.M., Boyle J.M., Heighway J., Birch J.M., Scott D. Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation. Int. J. Radiat. Biol. 70:145-150(1996) PubMed=9018113; DOI=10.1038/sj.onc.1200838 Williams K.J., Boyle J.M., Birch J.M., Norton J.D., Scott D. Cell cycle arrest defect in Li-Fraumeni syndrome: a mechanism of cancer predisposition? Oncogene 14:277-282(1997) PubMed=9649131; DOI=10.1038/bjc.1998.364; PMCID=PMC2150396 Boyle J.M., Mitchell E.L.D., Greaves M.J., Roberts S.A., Tricker K., Burt E., Varley J.M., Birch J.M., Scott D. Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families. Br. J. Cancer 77:2181-2192(1998)
Encyclopedic resources	Wikidata; Q98125104
Entry history
Entry creation	02-Jul-2020
Last entry update	19-Dec-2024
Version number	8