Cellosaurus cell line 21MA (CVCL

Cross-references
Cell line name	21MA
Synonyms	21 Manchester
Accession	CVCL_ZT86
Resource Identification Initiative	To cite this cell line use: 21MA (RRID:CVCL_ZT86)
Comments	Senescence: Senesces at 44 PDL (PubMed=9649131). Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (PubMed=9649131).
Disease	Li-Fraumeni syndrome (NCIt: C3476) Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_ZT87 ! 138MA
Sex of cell	Male
Age at sampling	11Y
Category	Finite cell line
Publications	PubMed=9649131; DOI=10.1038/bjc.1998.364; PMCID=PMC2150396 John Michael Boyle, Erika L.D. Mitchell, Martin J. Greaves, Stephen A. Roberts, Katy Tricker, Emma Burt, Jennifer M. Varley, Jillian M. Birch, David Scott; Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families. Br. J. Cancer 77:2181-2192(1998)
Encyclopedic resources	Wikidata; Q98125347
Entry history
Entry creation	02-Jul-2020
Last entry update	19-Dec-2024
Version number	8