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Cellosaurus NLT (CVCL_ZL27)

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Cell line name NLT
Accession CVCL_ZL27
Resource Identification Initiative To cite this cell line use: NLT (RRID:CVCL_ZL27)
Comments Characteristics: Secretes more GnRH1 than the autologous cell line GN11 (Cellosaurus=CVCL_ZL25).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Brain, hypothalamus; UBERON=UBERON_0001898.
Cell type: GnRH neuron; CL=CL_0011111.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: Transgenic with human GNRH1 promoter-Tg(SV40).
Hierarchy Parent: CVCL_ZL19 (GN)
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=18406727; DOI=10.1016/1043-2760(95)00228-6
Margaret E. Wierman, Zhao-Qin Fang, Jadwiga K. Kepa;
GnRH gene expression in neuronal cell lines.
Trends Endocrinol. Metab. 7:60-65(1996)

PubMed=9139717; DOI=10.1074/jbc.272.19.12620
Shan-Jun Zhen, Ian C. Dunn, Susan Wray, Ying Liu, Patrick E. Chappell, Jon E. Levine, Sally Radovick;
An alternative gonadotropin-releasing hormone (GnRH) RNA splicing product found in cultured GnRH neurons and mouse hypothalamus.
J. Biol. Chem. 272:12620-12625(1997)

Cross-references
Encyclopedic resources Wikidata; Q98127943
Entry history
Entry creation02-Jul-2020
Last entry update14-Aug-2025
Version number8