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Cellosaurus GN11 (CVCL_ZL25)

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Cell line name GN11
Synonyms Gn11; Gn-11
Accession CVCL_ZL25
Resource Identification Initiative To cite this cell line use: GN11 (RRID:CVCL_ZL25)
Comments Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Brain, hypothalamus; UBERON=UBERON_0001898.
Cell type: GnRH neuron; CL=CL_0011111.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: Transgenic with human GNRH1 promoter-Tg(SV40).
Hierarchy Parent: CVCL_ZL19 (GN)
Children:
CVCL_ZL26 (GN11-EGFP)
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): Millipore=SCC188

Markers:
Mouse STR 1-110
Mouse STR 1-213
Mouse STR 2-19
Mouse STR 3-214
Mouse STR 4-219.3
Mouse STR 5-514
Mouse STR 6-415.3
Mouse STR 6-712
Mouse STR 7-128
Mouse STR 8-115
Mouse STR 11-215,16
Mouse STR 12-120
Mouse STR 13-115.2
Mouse STR 15-320.3
Mouse STR 17-215
Mouse STR 18-317
Mouse STR 19-212
Mouse STR X-126

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Publications

PubMed=18406727; DOI=10.1016/1043-2760(95)00228-6
Margaret E. Wierman, Zhao-Qin Fang, Jadwiga K. Kepa;
GnRH gene expression in neuronal cell lines.
Trends Endocrinol. Metab. 7:60-65(1996)

PubMed=9139717; DOI=10.1074/jbc.272.19.12620
Shan-Jun Zhen, Ian C. Dunn, Susan Wray, Ying Liu, Patrick E. Chappell, Jon E. Levine, Sally Radovick;
An alternative gonadotropin-releasing hormone (GnRH) RNA splicing product found in cultured GnRH neurons and mouse hypothalamus.
J. Biol. Chem. 272:12620-12625(1997)

PubMed=10830297; DOI=10.1210/endo.141.6.7494
Roberto Maggi, Federica Pimpinelli, Laura Molteni, Mario Milani, Luciano Martini, Flavio Piva;
Immortalized luteinizing hormone-releasing hormone neurons show a different migratory activity in vitro.
Endocrinology 141:2105-2112(2000)

PubMed=15471890; DOI=10.1093/hmg/ddh309
Anna Maria Cariboni, Federica Pimpinelli, Sophia Alison Colamarino, Roberta Zaninetti, Margherita Piccolella, Cristiano Rumio, Flavio Piva, Elena I. Rugarli, Roberto Maggi;
The product of X-linked Kallmann's syndrome gene (KAL1) affects the migratory activity of gonadotropin-releasing hormone (GnRH)-producing neurons.
Hum. Mol. Genet. 13:2781-2791(2004)

PubMed=16207762; DOI=10.1242/dev.02033
Anna Maria Cariboni, Sonja Rakic, Anastasia Liapi, Roberto Maggi, Andre Goffinet, John G. Parnavelas;
Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons.
Development 132:4709-4718(2005)

Cross-references
Cell line collections (Providers) Millipore; SCC188
Encyclopedic resources Wikidata; Q98126644
Entry history
Entry creation02-Jul-2020
Last entry update14-Aug-2025
Version number10