Cellosaurus cell line FTD3#6-PGRN (CVCL

Cellosaurus FTD3#6-PGRN (CVCL_ZI78)

Cross-references
Cell line name	FTD3#6-PGRN
Accession	CVCL_ZI78
Resource Identification Initiative	To cite this cell line use: FTD3#6-PGRN (RRID:CVCL_ZI78)
Comments	Characteristics: Using ZFN GRN was introduced in the AAVS1 safe harbor locus. Genetic integration: Method=ZFN; Gene=HGNC; HGNC:4601; GRN. Omics: Transcriptomics; RNAseq. Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:4601; GRN; Simple; c.-8+5G>C (IVS1+5G>C) (g-3826G>C); ClinVar=VCV000098119; Zygosity=Unspecified (PubMed=25556567).
Disease	Frontotemporal dementia (NCIt: C84719) Behavioral variant of frontotemporal dementia (ORDO: Orphanet_275864)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_ZI77 (FTD3#6-iPSC)
Category	Induced pluripotent stem cell
Publications	PubMed=25556567; DOI=10.1016/j.stemcr.2014.12.001; PMCID=PMC4297877 Susanna Raitano, Laura Ordovas, Louis De Muynck, Wen-Ting Guo, Ira Espuny-Camacho, Martine Geraerts, Satish Khurana, Kim Vanuytsel, Balazs I. Toth, Thomas Voets, Rik Vandenberghe ...Show all 16 authors... , Toni Cathomen, Ludo Van Den Bosch, Pierre Vanderhaeghen, Philip Van Damme, Catherine M. Verfaillie; Show fewer authors Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia. Stem Cell Reports 4:16-24(2015)
Encyclopedic resources	Wikidata; Q98126273
Entry history
Entry creation	02-Jul-2020
Last entry update	10-Apr-2025
Version number	10