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Cellosaurus RUD (CVCL_ZI13)

[Text version]
Cell line name RUD
Synonyms Raji(Brdu)
Accession CVCL_ZI13
Resource Identification Initiative To cite this cell line use: RUD (RRID:CVCL_ZI13)
Comments Population: African; Nigerian.
Selected for resistance to: ChEBI; CHEBI_472552; 5-bromo-2'-deoxyuridine (Bromodeoxyuridine; BrdU; BUdR).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0511 (Raji)
Children:
CVCL_6216 (DITRUD-1)CVCL_6218 (RUDPICAT-1)CVCL_6219 (RUDPUT-2)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
Publications

PubMed=4550511; DOI=10.1073/pnas.69.1.78; PMCID=PMC427548
Berge Hampar, Jeffrey Gesell Derge, Lidia M. Martos, John L. Walker;
Synthesis of Epstein-Barr virus after activation of the viral genome in a 'virus-negative' human lymphoblastoid cell (Raji) made resistant to 5-bromodeoxyuridine.
Proc. Natl. Acad. Sci. U.S.A. 69:78-82(1972)

PubMed=6278187; DOI=10.1093/jnci/68.2.179
Jesper Zeuthen, George Klein, Rosalie Ber, Giuseppe Masucci, Susanne Bisballe, Susan Povey, Paul Ichiro Terasaki, Peter Ralph;
Human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. I Isolation, characterization, cell surface markers, and B-cell markers.
J. Natl. Cancer Inst. 68:179-195(1982)

PubMed=6278188; DOI=10.1093/jnci/68.2.197
George Klein, Jesper Zeuthen, Rosalie Ber, Ingemar Ernberg;
Human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. II Epstein-Barr virus induction patterns.
J. Natl. Cancer Inst. 68:197-202(1982)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZI13
Encyclopedic resources Wikidata; Q98129216
Entry history
Entry creation02-Jul-2020
Last entry update19-Dec-2024
Version number10