Cellosaurus cell line A388.6TG.c2.neoc1 (CVCL

Cellosaurus A388.6TG.c2.neoc1 (CVCL_ZF54)

Cross-references
Cell line name	A388.6TG.c2.neoc1
Synonyms	A3886TGc2 Neo c1
Accession	CVCL_ZF54
Resource Identification Initiative	To cite this cell line use: A388.6TG.c2.neoc1 (RRID:CVCL_ZF54)
Comments	Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG). Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg832Cys (c.2494C>T); ClinVar=VCV000936373; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Heterozygous (from parent cell line).
Disease	Skin squamous cell carcinoma (NCIt: C4819)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_ZF53 (A388.6TG.c2)
Sex of cell	Male
Age at sampling	86Y
Category	Cancer cell line
Publications	PubMed=1358434 Kathleen Conway, David Morgan, Karen K. Phillips, Stuart Howard Yuspa, Bernard E. Weissman; Tumorigenic suppression of a human cutaneous squamous cell carcinoma cell line in the nude mouse skin graft assay. Cancer Res. 52:6487-6495(1992) PubMed=10942591; DOI=10.1006/excr.2000.4946 Raymond V. Merrihew, Rachael D. Cruickshank, Kathleen Conway, Bernard E. Weissman; Altered response of a human squamous cell carcinoma cell line to 1, 25-dihydroxyvitamin D(3) after transfer of a normal chromosome 11. Exp. Cell Res. 259:191-203(2000)
Cell line databases/resources	cancercelllines; CVCL_ZF54
Encyclopedic resources	Wikidata; Q98125449
Entry history
Entry creation	02-Jul-2020
Last entry update	14-Aug-2025
Version number	9