Cellosaurus cell line A388.6TG.c2 (CVCL

Cellosaurus A388.6TG.c2 (CVCL_ZF53)

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Cell line name

A388.6TG.c2

Synonyms

A3886TGc2

Accession

CVCL_ZF53

Resource Identification Initiative

To cite this cell line use: A388.6TG.c2 (RRID:CVCL_ZF53)

Comments

Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

Sequence variations

Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg832Cys (c.2494C>T); ClinVar=VCV000936373; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Heterozygous (from parent cell line).

Disease

Skin squamous cell carcinoma (NCIt: C4819)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_1063 (A-388)
Children:

CVCL_ZF54 (A388.6TG.c2.neoc1)

Sex of cell

Male

Age at sampling

86Y