Cellosaurus cell line 22Rv1-undup1 (CVCL

Cellosaurus 22Rv1-undup1 (CVCL_ZC64)

Cross-references
Cell line name	22Rv1-undup1
Accession	CVCL_ZC64
Resource Identification Initiative	To cite this cell line use: 22Rv1-undup1 (RRID:CVCL_ZC64)
Comments	Population: Caucasian. Characteristics: The 35Kb tandem duplication of exons 2b-3-CE1-3 of AR that drives the expression of AR variant 7 (ARv7) was corrected using TALEN (PubMed=28928128). Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Leu597Arg (c.1790T>G); ClinVar=VCV000013968; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Arg1252Ter (c.3754C>T); ClinVar=VCV000167228; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Gln3158Ter (c.9472C>T); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gln546Arg (c.1637A>G); ClinVar=VCV000045466; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Heterozygous (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1045 (22Rv1)
Sex of cell	Male
Age at sampling	Adult
Category	Cancer cell line
Publications	PubMed=28928128; DOI=10.1158/0008-5472.CAN-17-0320; PMCID=PMC5654612 Jamie L. Van Etten, Michael D. Nyquist, Ying-Ming Li, Ren-Dong Yang, Yeung Ho, Rachel Johnson, Olivia Ondigi, Daniel F. Voytas, Christine Henzler, Scott M. Dehm; Targeting a single alternative polyadenylation site coordinately blocks expression of androgen receptor mRNA splice variants in prostate cancer. Cancer Res. 77:5228-5235(2017)
Cell line collections (Providers)	Kerafast; EMN025-FP
Cell line databases/resources	cancercelllines; CVCL_ZC64
Encyclopedic resources	Wikidata; Q98125354
Entry history
Entry creation	02-Jul-2020
Last entry update	19-Dec-2024
Version number	9