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Cellosaurus Cre4 rho-0#11 (CVCL_ZB95)

[Text version]
Cell line name Cre4 rho-0#11
Accession CVCL_ZB95
Resource Identification Initiative To cite this cell line use: Cre4 rho-0#11 (RRID:CVCL_ZB95)
Comments Characteristics: Cell line devoid of mitochondrial DNA (rho0). Produced by propagation for 3 weeks of the parent cell line in a medium containing 5 ug/ml EtBr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transgenic mouse; Gene=MGI; MGI:1352467; Esr1 (Note=Ligand binding domain; with p.Gly525Arg. Fused to Cre = CreERT2).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P06956; Escherichia phage P1 cre (Note=Fused to ligand domain of mouse Esr1 = CreERT2).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: B6.Cg-Tg(CAG-cre/Esr1)5Amc/J x Lig3LoxP.
Hierarchy Parent: CVCL_ZB94 (Cre4)
Sex of cell Sex unspecified
Age at sampling 13-14FD
Category Transformed cell line
Publications

PubMed=23884459; DOI=10.1074/jbc.M113.472977; PMCID=PMC3772206
Shokolenko I.N., Fayzulin R.Z., Katyal S., McKinnon P.J., Wilson G.L., Alexeyev M.F.
Mitochondrial DNA ligase is dispensable for the viability of cultured cells but essential for mtDNA maintenance.
J. Biol. Chem. 288:26594-26605(2013)

Cross-references
Cell line collections (Providers) Kerafast; ESA108
Encyclopedic resources Wikidata; Q98125689
Entry history
Entry creation02-Jul-2020
Last entry update10-Apr-2025
Version number8