ID   Cre4 rho-0#11
AC   CVCL_ZB95
DR   Kerafast; ESA108
DR   Wikidata; Q98125689
RX   PubMed=23884459;
CC   Characteristics: Cell line devoid of mitochondrial DNA (rho0). Produced by propagation for 3 weeks of the parent cell line in a medium containing 5 ug/ml EtBr.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transgenic mouse; Gene=MGI; MGI:1352467; Esr1 (Note=Ligand binding domain; with p.Gly525Arg. Fused to Cre = CreERT2).
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P06956; Escherichia phage P1 cre (Note=Fused to ligand domain of mouse Esr1 = CreERT2).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
CC   Cell type: Fibroblast; CL=CL_0000057.
CC   Breed/subspecies: B6.Cg-Tg(CAG-cre/Esr1)5Amc/J x Lig3LoxP.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_ZB94 ! Cre4
SX   Sex unspecified
AG   13-14FD
CA   Transformed cell line
DT   Created: 02-07-20; Last updated: 10-04-25; Version: 8
//
RX   PubMed=23884459; DOI=10.1074/jbc.M113.472977; PMCID=PMC3772206;
RA   Shokolenko I.N., Fayzulin R.Z., Katyal S., McKinnon P.J., Wilson G.L.,
RA   Alexeyev M.F.;
RT   "Mitochondrial DNA ligase is dispensable for the viability of cultured
RT   cells but essential for mtDNA maintenance.";
RL   J. Biol. Chem. 288:26594-26605(2013).
//