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Cellosaurus KY-ADR2 (CVCL_Z940)

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Cell line name KY-ADR2
Accession CVCL_Z940
Resource Identification Initiative To cite this cell line use: KY-ADR2 (RRID:CVCL_Z940)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Brain, meninges; UBERON=UBERON_0010743.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000375871; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Adult acute myelomonocytic leukemia (NCIt: C7962)
Acute myelomonocytic leukemia (ORDO: Orphanet_517)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1346 (KY821)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Publications

PubMed=7934146; DOI=10.1016/0145-2126(94)90071-X
Takeaki Fukuda, Toshio Kakihara, Tomoko Kamishima, Yoshihisa Ohnishi, Makoto Naito, Kenji Kishi, Akira Shibata, Takashi Tsuruo;
Characterization of newly established adriamycin resistant human leukemic cell lines (KY-ADR1 and KY-ADR2).
Leuk. Res. 18:709-715(1994)

PubMed=12716468; DOI=10.1111/j.1349-7006.2002.tb01336.x; PMCID=PMC5927113
Hajime Shimizu, Takeaki Fukuda, Mohammad Ghazizadeh, Mikio Nagashima, Oichi Kawanami, Toshimitsu Suzuki;
Molecular cytogenetic characterization of drug-resistant leukemia cell lines by comparative genomic hybridization and fluorescence in situ hybridization.
Jpn. J. Cancer Res. 93:902-910(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_Z940
Encyclopedic resources Wikidata; Q54900769
Entry history
Entry creation10-Apr-2015
Last entry update14-Aug-2025
Version number14