Cellosaurus cell line 4a-3B (CVCL

Cellosaurus 4a-3B (CVCL_Z623)

Cross-references
Cell line name	4a-3B
Synonyms	4A-3B; 4a3B; 4a3b
Accession	CVCL_Z623
Resource Identification Initiative	To cite this cell line use: 4a-3B (RRID:CVCL_Z623)
Comments	Group: Insect cell line. Group: Malaria research cell line. Characteristics: Expresses constitutively six prophenoloxidase (PPO) genes (PubMed=10206988). Omics: Genomics; Whole genome sequencing. Omics: Transcriptomics; RNAseq. Derived from site: In situ; Hemolymph; UBERON=UBERON_0001011. Cell type: Hemocyte; CL=CL_0000387.
Species of origin	Anopheles gambiae (African malaria mosquito) (NCBI Taxonomy: 7165) Breed/subspecies: 4a r/r.
Originate from same individual	CVCL_Z622 ! 4a-3A
Sex of cell	Female
Age at sampling	Neonate larva
Category	Spontaneously immortalized cell line
Publications	PubMed=10206988; DOI=10.1074/jbc.274.17.11727 Hans-Michael Muller, George Dimopoulos, Claudia Blass, Fotis Constantine Kafatos; A hemocyte-like cell line established from the malaria vector Anopheles gambiae expresses six prophenoloxidase genes. J. Biol. Chem. 274:11727-11735(1999) PubMed=23382679; DOI=10.1371/journal.ppat.1003145; PMCID=PMC3561300 Fabrizio Lombardo, Yasmeen Ghani, Fotis Constantine Kafatos, George K. Christophides; Comprehensive genetic dissection of the hemocyte immune response in the malaria mosquito Anopheles gambiae. PLoS Pathog. 9:e1003145.1-e1003145.11(2013) PubMed=36514125; DOI=10.1186/s13071-022-05590-3; PMCID=PMC9749150 Heather Eggleston, Kimani Njoya, Cameron E. Anderson, Inge Holm, Karin Eiglmeier, Jiang-Tao Liang, Igor V. Sharakhov, Kenneth D. Vernick, Michelle M. Riehle; Molecular characterization and genetic authentication assay for Anopheles 'hemocyte-like' cell lines 4a-3A and 4a-3B. Parasit. Vectors 15:465.1-465.13(2022)
Cell line collections (Providers)	BEI_Resources; MRA-919
Encyclopedic resources	Wikidata; Q54603337
Entry history
Entry creation	10-Apr-2015
Last entry update	10-Apr-2025
Version number	12