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Cellosaurus IOSE11CMYC.KRAS (CVCL_YZ58)

[Text version]
Cell line name IOSE11CMYC.KRAS
Synonyms IOSE11+CMYC+KRAS; IOE11CMYC.KRAS
Accession CVCL_YZ58
Resource Identification Initiative To cite this cell line use: IOSE11CMYC.KRAS (RRID:CVCL_YZ58)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6407; KRAS (Note=With p.Gly12Val (c.35G>T)).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_YZ54 (IOSE11CMYC)
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=21859834; DOI=10.1093/carcin/bgr140
Lawrenson K., Sproul D., Grun B., Notaridou M., Benjamin E., Jacobs I.J., Dafou D., Sims A.H., Gayther S.A.
Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.
Carcinogenesis 32:1540-1549(2011)

PubMed=25204737; DOI=10.1002/ijc.29197
Lawrenson K., Mhawech-Fauceglia P., Worthington J., Spindler T.J., O'Brien D., Lee J.M., Spain G., Sharifian M., Wang G.-S., Darcy K.M., Pejovic T., Sowter H.M., Timms J.F., Gayther S.A.
Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the secretomes of three-dimensional genetic models of ovarian carcinogenesis.
Int. J. Cancer 137:1806-1817(2015)

Cross-references
Encyclopedic resources Wikidata; Q98126778
Entry history
Entry creation02-Jul-2020
Last entry update10-Apr-2025
Version number9