ID   IOSE11CMYC.KRAS
AC   CVCL_YZ58
SY   IOSE11+CMYC+KRAS; IOE11CMYC.KRAS
DR   Wikidata; Q98126778
RX   PubMed=21859834;
RX   PubMed=25204737;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6407; KRAS (Note=With p.Gly12Val (c.35G>T)).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_YZ54 ! IOSE11CMYC
SX   Female
AG   Age unspecified
CA   Telomerase immortalized cell line
DT   Created: 02-07-20; Last updated: 10-04-25; Version: 9
//
RX   PubMed=21859834; DOI=10.1093/carcin/bgr140;
RA   Lawrenson K., Sproul D., Grun B., Notaridou M., Benjamin E.,
RA   Jacobs I.J., Dafou D., Sims A.H., Gayther S.A.;
RT   "Modelling genetic and clinical heterogeneity in epithelial ovarian
RT   cancers.";
RL   Carcinogenesis 32:1540-1549(2011).
//
RX   PubMed=25204737; DOI=10.1002/ijc.29197;
RA   Lawrenson K., Mhawech-Fauceglia P., Worthington J., Spindler T.J.,
RA   O'Brien D., Lee J.M., Spain G., Sharifian M., Wang G.-S., Darcy K.M.,
RA   Pejovic T., Sowter H.M., Timms J.F., Gayther S.A.;
RT   "Identification of novel candidate biomarkers of epithelial ovarian
RT   cancer by profiling the secretomes of three-dimensional genetic models
RT   of ovarian carcinogenesis.";
RL   Int. J. Cancer 137:1806-1817(2015).
//