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Cellosaurus IOSE19CMYC (CVCL_YZ55)

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Cell line name IOSE19CMYC
Synonyms IOSE19+CMYC; IOE19CMYC
Accession CVCL_YZ55
Resource Identification Initiative To cite this cell line use: IOSE19CMYC (RRID:CVCL_YZ55)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0T69 (IOSE19)
Children:
CVCL_YZ59 (IOSE19CMYC.BRAF)CVCL_YZ60 (IOSE19CMYC.KRAS)
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=20360942; DOI=10.1593/neo.91948; PMCID=PMC2847739
Kate Lawrenson, Barbara Grun, Elizabeth Benjamin, Ian J. Jacobs, Dimitra Dafou, Simon Andrew Gayther;
Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer.
Neoplasia 12:317-325(2010)

PubMed=21859834; DOI=10.1093/carcin/bgr140
Kate Lawrenson, Duncan Sproul, Barbara Grun, Maria Notaridou, Elizabeth Benjamin, Ian J. Jacobs, Dimitra Dafou, Andrew H. Sims, Simon Andrew Gayther;
Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.
Carcinogenesis 32:1540-1549(2011)

PubMed=25204737; DOI=10.1002/ijc.29197
Kate Lawrenson, Paulette Mhawech-Fauceglia, Jenny Worthington, Tassja J. Spindler, Darragh O'Brien, Janet M. Lee, Georgia Spain, Maryam Sharifian, Gui-Song Wang, Kathleen M. Darcy, Tanja Pejovic ...Show all 14 authors... , Heidi M. Sowter, John F. Timms, Simon Andrew Gayther; Show fewer authors
Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the secretomes of three-dimensional genetic models of ovarian carcinogenesis.
Int. J. Cancer 137:1806-1817(2015)

Cross-references
Encyclopedic resources Wikidata; Q98126781
Entry history
Entry creation02-Jul-2020
Last entry update14-Aug-2025
Version number11