ID   IOSE19CMYC
AC   CVCL_YZ55
SY   IOSE19+CMYC; IOE19CMYC
DR   Wikidata; Q98126781
RX   PubMed=20360942;
RX   PubMed=21859834;
RX   PubMed=25204737;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0T69 ! IOSE19
SX   Female
AG   Age unspecified
CA   Telomerase immortalized cell line
DT   Created: 02-07-20; Last updated: 14-08-25; Version: 11
CH   CVCL_YZ59 ! IOSE19CMYC.BRAF
CH   CVCL_YZ60 ! IOSE19CMYC.KRAS
//
RX   PubMed=21859834; DOI=10.1093/carcin/bgr140;
RA   Lawrenson, Kate
RA   Sproul, Duncan
RA   Grun, Barbara
RA   Notaridou, Maria
RA   Benjamin, Elizabeth
RA   Jacobs, Ian J.
RA   Dafou, Dimitra
RA   Sims, Andrew H.
RA   Gayther, Simon Andrew
RT   "Modelling genetic and clinical heterogeneity in epithelial ovarian
RT   cancers.";
RL   Carcinogenesis 32:1540-1549(2011).
//
RX   PubMed=25204737; DOI=10.1002/ijc.29197;
RA   Lawrenson, Kate
RA   Mhawech-Fauceglia, Paulette
RA   Worthington, Jenny
RA   Spindler, Tassja J.
RA   O'Brien, Darragh
RA   Lee, Janet M.
RA   Spain, Georgia
RA   Sharifian, Maryam
RA   Wang, Gui-Song
RA   Darcy, Kathleen M.
RA   Pejovic, Tanja
RA   Sowter, Heidi M.
RA   Timms, John F.
RA   Gayther, Simon Andrew
RT   "Identification of novel candidate biomarkers of epithelial ovarian
RT   cancer by profiling the secretomes of three-dimensional genetic models
RT   of ovarian carcinogenesis.";
RL   Int. J. Cancer 137:1806-1817(2015).
//
RX   PubMed=20360942; DOI=10.1593/neo.91948; PMCID=PMC2847739;
RA   Lawrenson, Kate
RA   Grun, Barbara
RA   Benjamin, Elizabeth
RA   Jacobs, Ian J.
RA   Dafou, Dimitra
RA   Gayther, Simon Andrew
RT   "Senescent fibroblasts promote neoplastic transformation of partially
RT   transformed ovarian epithelial cells in a three-dimensional model of
RT   early stage ovarian cancer.";
RL   Neoplasia 12:317-325(2010).
//