Cellosaurus cell line NCC-MPNST1-C1 (CVCL

Cellosaurus NCC-MPNST1-C1 (CVCL_YU12)

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Cell line name

NCC-MPNST1-C1

Synonyms

NCCMPNST1C1

Accession

CVCL_YU12

Resource Identification Initiative

To cite this cell line use: NCC-MPNST1-C1 (RRID:CVCL_YU12)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: NCC sarcoma cell line panel.
Population: Japanese.
Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo, Tadashi).
Doubling time: 28 hours (PubMed=32099531).
Omics: Phenotyping; Drug screening.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=32099531).
Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (PubMed=32099531).
Gene deletion; HGNC; HGNC:12362; TSC1; Zygosity=Homozygous (PubMed=32099531).
Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Lys1872Ter (c.5614A>T); ClinVar=VCV000037979; Zygosity=Heterozygous (PubMed=32099531).

Disease

Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

37Y

Category

Cancer cell line

STR profile

Source(s): PubMed=32099531

Markers:

Amelogenin	X
CSF1PO	12
D5S818	7,13
D7S820	10.3,11
D13S317	11,12
D16S539	10,11
D21S11	30,31
TH01	6
TPOX	11
vWA	17,18

Publications

PubMed=32099531; DOI=10.1186/s12935-020-1128-z; PMCID=PMC7031935
Rieko Oyama, Fusako Kito, Mami Takahashi, Emi Hattori, Rei Noguchi, Yoko Takai, Marimu Sakumoto, Zhi-Wei Qiao, Shunichi Toki, Masato Sugawara, Yoshikazu Tanzawa ...Show all 17 authors... , Eisuke Kobayashi, Fumihiko Nakatani, Shintaro Iwata, Akihiko Yoshida, Akira Kawai, Tadashi Kondo; Show fewer authors
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors.
Cancer Cell Int. 20:58.1-58.15(2020)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_YU12
DepMap; ACH-002799

Encyclopedic resources

Wikidata; Q95992534

Entry history

Entry creation

12-Mar-2020

Last entry update

27-Nov-2025

Version number