ID   NCC-MPNST1-C1
AC   CVCL_YU12
SY   NCCMPNST1C1
DR   cancercelllines; CVCL_YU12
DR   DepMap; ACH-002799
DR   Wikidata; Q95992534
RX   PubMed=32099531;
WW   Provider; BizCom; -; https://en.cellline.jp/product/ncc-mpnst1-c1/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: NCC sarcoma cell line panel.
CC   Population: Japanese.
CC   Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo, Tadashi).
CC   Doubling time: 28 hours (PubMed=32099531).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=32099531).
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (PubMed=32099531).
CC   Sequence variation: Gene deletion; HGNC; HGNC:12362; TSC1; Zygosity=Homozygous (PubMed=32099531).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Lys1872Ter (c.5614A>T); ClinVar=VCV000037979; Zygosity=Heterozygous (PubMed=32099531).
CC   Omics: Phenotyping; Drug screening.
ST   Source(s): PubMed=32099531
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11,12
ST   D16S539: 10,11
ST   D21S11: 30,31
ST   D5S818: 7,13
ST   D7S820: 10.3,11
ST   TH01: 6
ST   TPOX: 11
ST   vWA: 17,18
DI   NCIt; C3798; Malignant peripheral nerve sheath tumor
DI   NCIt; C3273; Neurofibromatosis type 1
DI   ORDO; Orphanet_3148; Malignant peripheral nerve sheath tumor
DI   ORDO; Orphanet_636; Neurofibromatosis type 1
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   37Y
CA   Cancer cell line
DT   Created: 12-03-20; Last updated: 10-04-25; Version: 12
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RX   PubMed=32099531; DOI=10.1186/s12935-020-1128-z; PMCID=PMC7031935;
RA   Oyama R., Kito F., Takahashi M., Hattori E., Noguchi R., Takai Y.,
RA   Sakumoto M., Qiao Z.-W., Toki S., Sugawara M., Tanzawa Y., Kobayashi E.,
RA   Nakatani F., Iwata S., Yoshida A., Kawai A., Kondo T.;
RT   "Establishment and characterization of patient-derived cancer models
RT   of malignant peripheral nerve sheath tumors.";
RL   Cancer Cell Int. 20:58.1-58.15(2020).
//