Cellosaurus cell line ssHUDEP2 (CVCL

Cross-references
Cell line name	ssHUDEP2
Accession	CVCL_YT59
Resource Identification Initiative	To cite this cell line use: ssHUDEP2 (RRID:CVCL_YT59)
Comments	Population: Japanese. Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6. Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Umbilical cord blood; UBERON=UBERON_0012168. Cell type: Erythroid progenitor cell; CL=CL_0000038.
Sequence variations	Mutation; HGNC; 4827; HBB; Simple_edited; p.Glu7Val (c.20A>T) (E6V); ClinVar=VCV000015333; Zygosity=Homozygous; Note=By CRISPR/Cas9 (DOI=10.1182/blood-2019-127330).
Disease	Sickle cell disease (NCIt: C34383) Sickle cell anemia (ORDO: Orphanet_232)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_VI06 (HUDEP-2)
Sex of cell	Sex unspecified
Age at sampling	<1D
Category	Transformed cell line
Publications	DOI=10.1182/blood-2019-127330 Gupta D., Sturtevant S., Vieira B., Nakamura Y., Krishnamoorthy S., Demers M. Characterization of a genetically engineered HUDEP2 cell line harboring a sickle cell disease mutation as a potential research tool for preclinical sickle cell disease drug discovery. Blood 134 Suppl. 1:3559a-3559a(2019)
Encyclopedic resources	Wikidata; Q98132831
Entry history
Entry creation	12-Mar-2020
Last entry update	05-Oct-2023
Version number	9