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Cellosaurus VeroE6/TMPRSS2 (CVCL_YQ49)

[Text version]
Cell line name VeroE6/TMPRSS2
Accession CVCL_YQ49
Resource Identification Initiative To cite this cell line use: VeroE6/TMPRSS2 (RRID:CVCL_YQ49)
Comments Group: Non-human primate cell line.
Group: SARS-CoV-2 research cell line.
Virology: Highly susceptible to infection by Middle East respiratory syndrome-related coronavirus (MERS-CoV), SARS coronavirus (SARS-CoV) and SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=32165541).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11876; TMPRSS2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Kidney, epithelium; UBERON=UBERON_0004819.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Chlorocebus sabaeus (Green monkey) (Simia sabaea) (NCBI Taxonomy: 60711)
Hierarchy Parent: CVCL_0574 (Vero C1008)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages Provider; NIBSC; 100978; https://www.nibsc.org/products/brm_product_catalogue/detail_page.aspx?catid=100978
Publications

PubMed=31013314; DOI=10.1371/journal.pone.0215822; PMCID=PMC6478314
Nao N., Sato K., Yamagishi J., Tahara M., Nakatsu Y., Seki F., Katoh H., Ohnuma A., Shirogane Y., Hayashi M., Suzuki T., Kikuta H., Nishimura H., Takeda M.
Consensus and variations in cell line specificity among human metapneumovirus strains.
PLoS ONE 14:e0215822.1-e0215822.21(2019)

PubMed=32165541; DOI=10.1073/pnas.2002589117; PMCID=PMC7132130
Matsuyama S., Nao N., Shirato K., Kawase M., Saito S., Takayama I., Nagata N., Sekizuka T., Katoh H., Kato F., Sakata M., Tahara M., Kutsuna S., Ohmagari N., Kuroda M., Suzuki T., Kageyama T., Takeda M.
Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.
Proc. Natl. Acad. Sci. U.S.A. 117:7001-7003(2020)

Cross-references
Cell line collections (Providers) JCRB; JCRB1819
Encyclopedic resources Wikidata; Q91354600
Entry history
Entry creation12-Mar-2020
Last entry update10-Apr-2025
Version number11