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Cellosaurus VeroE6/TMPRSS2 (CVCL_YQ49)

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Cell line name VeroE6/TMPRSS2
Accession CVCL_YQ49
Resource Identification Initiative To cite this cell line use: VeroE6/TMPRSS2 (RRID:CVCL_YQ49)
Comments Group: Non-human primate cell line.
Group: SARS-CoV-2 research cell line.
Virology: Highly susceptible to infection by Middle East respiratory syndrome-related coronavirus (MERS-CoV), SARS coronavirus (SARS-CoV) and SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=32165541).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11876; TMPRSS2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Kidney, epithelium; UBERON=UBERON_0004819.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Chlorocebus sabaeus (Green monkey) (Simia sabaea) (NCBI Taxonomy: 60711)
Hierarchy Parent: CVCL_0574 (Vero C1008)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages Provider; NIBSC; 100978; https://www.nibsc.org/products/brm_product_catalogue/detail_page.aspx?catid=100978
Publications

PubMed=31013314; DOI=10.1371/journal.pone.0215822; PMCID=PMC6478314
Naganori Nao, Ko Sato, Junya Yamagishi, Maino Tahara, Yuichiro Nakatsu, Fumio Seki, Hiroshi Katoh, Aiko Ohnuma, Yuta Shirogane, Masahiro Hayashi, Tamio Suzuki ...Show all 14 authors... , Hideaki Kikuta, Hidekazu Nishimura, Makoto Takeda; Show fewer authors
Consensus and variations in cell line specificity among human metapneumovirus strains.
PLoS ONE 14:e0215822.1-e0215822.21(2019)

PubMed=32165541; DOI=10.1073/pnas.2002589117; PMCID=PMC7132130
Shutoku Matsuyama, Naganori Nao, Kazuya Shirato, Miyuki Kawase, Shinji Saito, Ikuyo Takayama, Noriyo Nagata, Tsuyoshi Sekizuka, Hiroshi Katoh, Fumihiro Kato, Masafumi Sakata ...Show all 18 authors... , Maino Tahara, Satoshi Kutsuna, Norio Ohmagari, Makoto Kuroda, Tadaki Suzuki, Tsutomu Kageyama, Makoto Takeda; Show fewer authors
Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.
Proc. Natl. Acad. Sci. U.S.A. 117:7001-7003(2020)

Cross-references
Cell line collections (Providers) JCRB; JCRB1819
Encyclopedic resources Wikidata; Q91354600
Entry history
Entry creation12-Mar-2020
Last entry update14-Aug-2025
Version number12