ID   VeroE6/TMPRSS2
AC   CVCL_YQ49
DR   JCRB; JCRB1819
DR   Wikidata; Q91354600
RX   PubMed=31013314;
RX   PubMed=32165541;
WW   Provider; NIBSC; 100978; https://www.nibsc.org/products/brm_product_catalogue/detail_page.aspx?catid=100978
CC   Group: Non-human primate cell line.
CC   Group: SARS-CoV-2 research cell line.
CC   Virology: Highly susceptible to infection by Middle East respiratory syndrome-related coronavirus (MERS-CoV), SARS coronavirus (SARS-CoV) and SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=32165541).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11876; TMPRSS2.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: In situ; Kidney, epithelium; UBERON=UBERON_0004819.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
OX   NCBI_TaxID=60711; ! Chlorocebus sabaeus (Green monkey)
HI   CVCL_0574 ! Vero C1008
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 12-03-20; Last updated: 14-08-25; Version: 12
//
RX   PubMed=31013314; DOI=10.1371/journal.pone.0215822; PMCID=PMC6478314;
RA   Nao, Naganori
RA   Sato, Ko
RA   Yamagishi, Junya
RA   Tahara, Maino
RA   Nakatsu, Yuichiro
RA   Seki, Fumio
RA   Katoh, Hiroshi
RA   Ohnuma, Aiko
RA   Shirogane, Yuta
RA   Hayashi, Masahiro
RA   Suzuki, Tamio
RA   Kikuta, Hideaki
RA   Nishimura, Hidekazu
RA   Takeda, Makoto
RT   "Consensus and variations in cell line specificity among human
RT   metapneumovirus strains.";
RL   PLoS ONE 14:e0215822.1-e0215822.21(2019).
//
RX   PubMed=32165541; DOI=10.1073/pnas.2002589117; PMCID=PMC7132130;
RA   Matsuyama, Shutoku
RA   Nao, Naganori
RA   Shirato, Kazuya
RA   Kawase, Miyuki
RA   Saito, Shinji
RA   Takayama, Ikuyo
RA   Nagata, Noriyo
RA   Sekizuka, Tsuyoshi
RA   Katoh, Hiroshi
RA   Kato, Fumihiro
RA   Sakata, Masafumi
RA   Tahara, Maino
RA   Kutsuna, Satoshi
RA   Ohmagari, Norio
RA   Kuroda, Makoto
RA   Suzuki, Tadaki
RA   Kageyama, Tsutomu
RA   Takeda, Makoto
RT   "Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 117:7001-7003(2020).
//