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Cellosaurus A549/Asc-1 (CVCL_YA87)

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Cell line name A549/Asc-1
Synonyms A549/ASC-1
Accession CVCL_YA87
Resource Identification Initiative To cite this cell line use: A549/Asc-1 (RRID:CVCL_YA87)
Comments Population: Caucasian.
Characteristics: Established following in vivo propagation of parent cell line as an ascites tumor (PubMed=3129183).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=3129183
Walter C. Hubbard, Michael Curtis Alley, Theodore L. McLemore, Michael R. Boyd;
Evidence for thromboxane biosynthesis in established cell lines derived from human lung adenocarcinomas.
Cancer Res. 48:2674-2677(1988)

PubMed=3335022
Michael Curtis Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YA87
Encyclopedic resources Wikidata; Q93312009
Gene expression databases GEO; GSM1177927
GEO; GSM1177928
Entry history
Entry creation19-Dec-2019
Last entry update27-Nov-2025
Version number10