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Cellosaurus HSC3/hPDPN (CVCL_YA14)

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Cell line name HSC3/hPDPN
Synonyms HSC3-hPDPN
Accession CVCL_YA14
Resource Identification Initiative To cite this cell line use: HSC3/hPDPN (RRID:CVCL_YA14)
Comments Population: Japanese.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:29602; PDPN.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu120Ter (c.358G>T); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Gly (c.1634A>G); ClinVar=VCV000013656; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys305fs (c.912_913insTAAG); Zygosity=Unspecified (from parent cell line).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1288 (HSC-3)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=23012488; DOI=10.1267/ahc.12008; PMCID=PMC3445762
Chiaki Kaji, Yuta Tsujimoto, Mika Kato Kaneko, Yukinari Kato, Yoshihiko Sawa;
Immunohistochemical examination of novel rat monoclonal antibodies against mouse and human podoplanin.
Acta Histochem. Cytochem. 45:227-237(2012)

PubMed=25080943; DOI=10.1038/srep05924; PMCID=PMC4118152
Yukinari Kato, Mika Kato Kaneko;
A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplanin.
Sci. Rep. 4:5924.1-5924.9(2014)

PubMed=28387591; DOI=10.1089/mab.2017.0001
Shinji Yamada, Satoshi Ogasawara, Mika Kato Kaneko, Yukinari Kato;
LpMab-23: a cancer-specific monoclonal antibody against human podoplanin.
Monoclon. Antib. Immunodiagn. Immunother. 36:72-76(2017)

Cross-references
Encyclopedic resources Wikidata; Q94302977
Entry history
Entry creation19-Dec-2019
Last entry update14-Aug-2025
Version number12