Cellosaurus cell line LA11 [Human iPSC] (CVCL

Cellosaurus LA11 [Human iPSC] (CVCL_Y951)

Cross-references
Cell line name	LA11 [Human iPSC]
Synonyms	PARK8-LA11; HPS0103
Accession	CVCL_Y951
Resource Identification Initiative	To cite this cell line use: LA11 [Human iPSC] (RRID:CVCL_Y951)
Comments	Population: Japanese. Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:18618; LRRK2; Simple; p.Ile2020Thr (c.6059C>T); ClinVar=VCV000001941; Zygosity=Heterozygous (PubMed=26056228).
Disease	Parkinson disease 8, autosomal dominant (NCIt: C198605) Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_T963 ! LA3 CVCL_Y949 ! LA5 [Human iPSC] CVCL_Y950 ! LA8
Sex of cell	Female
Age at sampling	66Y
Category	Induced pluripotent stem cell
Publications	PubMed=26056228; DOI=10.1093/hmg/ddv212 Etsuro Ohta, Tomoko Nihira, Akiko Uchino, Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Kayoko Takahashi, Hideki Hayakawa, Makiko Nagai, Manabu Ohyama, Masafuchi Ryo ...Show all 19 authors... , Mieko Ogino, Shigeo Murayama, Akihiko Takashima, Kazutoshi Nishiyama, Yoshikuni Mizuno, Hideki Mochizuki, Fumiya Obata, Hideyuki Okano; Show fewer authors I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway. Hum. Mol. Genet. 24:4879-4900(2015)
Cell line databases/resources	SKIP; SKIP000992
Encyclopedic resources	Wikidata; Q54901885
Entry history
Entry creation	10-Apr-2015
Last entry update	10-Apr-2025
Version number	10