Cellosaurus cell line LA5 [Human iPSC] (CVCL

Cellosaurus LA5 [Human iPSC] (CVCL_Y949)

[Text version]

Cell line name

LA5 [Human iPSC]

Synonyms

PARK8-LA5; HPS0101

Accession

CVCL_Y949

Resource Identification Initiative

To cite this cell line use: LA5 [Human iPSC] (RRID:CVCL_Y949)

Comments

Population: Japanese.
Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
Cell type: Fibroblast of skin; CL=CL_0002620.

Sequence variations

Mutation; HGNC; HGNC:18618; LRRK2; Simple; p.Ile2020Thr (c.6059C>T); ClinVar=VCV000001941; Zygosity=Heterozygous (PubMed=26056228).

Disease

Parkinson disease 8, autosomal dominant (NCIt: C198605)
Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_A1YC (KEIUi001-A)

Originate from same individual

CVCL_T963 ! LA3
CVCL_Y950 ! LA8
CVCL_Y951 ! LA11 [Human iPSC]

Sex of cell

Female

Age at sampling

66Y

Category

Induced pluripotent stem cell

Publications

PubMed=26056228; DOI=10.1093/hmg/ddv212
Etsuro Ohta, Tomoko Nihira, Akiko Uchino, Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Kayoko Takahashi, Hideki Hayakawa, Makiko Nagai, Manabu Ohyama, Masafuchi Ryo ...Show all 19 authors... , Mieko Ogino, Shigeo Murayama, Akihiko Takashima, Kazutoshi Nishiyama, Yoshikuni Mizuno, Hideki Mochizuki, Fumiya Obata, Hideyuki Okano; Show fewer authors
I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway.
Hum. Mol. Genet. 24:4879-4900(2015)

Cross-references

Cell line databases/resources

SKIP; SKIP000991

Encyclopedic resources

Wikidata; Q54901888

Entry history

Entry creation

10-Apr-2015

Last entry update

10-Apr-2025

Version number